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RKI1 ribose-5-phosphate isomerase RKI1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854262, updated on 2-Nov-2024

Summary

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Official Symbol
RKI1
Official Full Name
ribose-5-phosphate isomerase RKI1
Primary source
SGD:S000005621
Locus tag
YOR095C
See related
AllianceGenome:SGD:S000005621; FungiDB:YOR095C; VEuPathDB:YOR095C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ribose-5-phosphate isomerase activity. Involved in pentose-phosphate shunt and pyridoxine biosynthetic process. Located in cytoplasm and nucleus. Orthologous to human RPIA (ribose 5-phosphate isomerase A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RKI1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (503552..504328, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Cmr2p Neighboring gene Arf family GTPase ARF3 Neighboring gene ribosomal 40S subunit protein S7A Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pyridoxine biosynthesis in yeast: participation of ribose 5-phosphate ketol-isomerase. Kondo H, et al. Biochem J, 2004 Apr 1. PMID 14690456, Free PMC Article
  2. Crystal structure of the S. cerevisiae D-ribose-5-phosphate isomerase: comparison with the archaeal and bacterial enzymes. Graille M, et al. Biochimie, 2005 Aug. PMID 16054529
  3. Cloning and characterization of the first two genes of the non-oxidative part of the Saccharomyces cerevisiae pentose-phosphate pathway. Miosga T, et al. Curr Genet, 1996 Nov. PMID 8929392
  4. Multilevel engineering of the upstream module of aromatic amino acid biosynthesis in Saccharomyces cerevisiae for high production of polymer and drug precursors. Suástegui M, et al. Metab Eng, 2017 Jul. PMID 28625755
  5. Regulation of tubulin polypeptides and microtubule function: Luv1p [correction of Rki1p] interacts with the beta-tubulin binding protein Rbl2p. Smith AM, et al. Chromosoma, 1998 Dec. PMID 9914379

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribose-5-phosphate isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribose-5-phosphate isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribose-5-phosphate isomerase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in D-ribose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pentose-phosphate shunt IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose-phosphate shunt IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pentose-phosphate shunt, non-oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pentose-phosphate shunt, non-oxidative branch IEA
Inferred from Electronic Annotation
more info
  
involved_in pyridoxine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in small molecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
ribose-5-phosphate isomerase RKI1
NP_014738.1
  • Ribose-5-phosphate ketol-isomerase; catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    503552..504328 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183514.1 → NP_014738.1  TPA: ribose-5-phosphate isomerase RKI1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014738.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZNU5, D6W2F6, Q12189
    UniProtKB/TrEMBL
    B3LJE1, C7GMN9, C8ZI56, G2WMX2, N1NWX9
    Conserved Domains (1) summary
    TIGR00021
    Location:22 → 253
    rpiA; ribose 5-phosphate isomerase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12189.1

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