RPO31 DNA-directed RNA polymerase III core subunit RPO31 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RPO31
Official Full Name: DNA-directed RNA polymerase III core subunit RPO31
Primary source: SGD:S000005642
Locus tag: YOR116C
See related: AllianceGenome:SGD:S000005642; FungiDB:YOR116C; VEuPathDB:YOR116C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: RPC1; RPC160
Summary: Contributes to RNA polymerase III activity. Involved in tRNA transcription by RNA polymerase III. Part of RNA polymerase III complex. Used to study hypomyelinating leukodystrophy and hypomyelinating leukodystrophy 7. Human ortholog(s) of this gene implicated in Wiedemann-Rautenstrauch syndrome and hypomyelinating leukodystrophy 7. Orthologous to human POLR3A (RNA polymerase III subunit A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RPO31 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (539763..544145, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

postulate that the degradation of C160 is activated under stress conditions to reduce the amount of existing Pol III complex and prevent its de novo assembly.
Title: Repression of yeast RNA polymerase III by stress leads to ubiquitylation and proteasomal degradation of its largest subunit, C160.
Yeast Bud27 modulates the biogenesis of Rpc128 and Rpc160 subunits and the assembly of RNA polymerase III.
Title: Yeast Bud27 modulates the biogenesis of Rpc128 and Rpc160 subunits and the assembly of RNA polymerase III.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 5'-3' RNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-directed 5'-3' RNA polymerase activity	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase III activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase III activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in tRNA transcription by RNA polymerase III	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase III complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase III complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA-directed RNA polymerase III core subunit RPO31

NP_014759.1

EC 2.7.7.6

RNA polymerase III largest subunit C160; part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

539763..544145 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183535.1 → NP_014759.1 TPA: DNA-directed RNA polymerase III core subunit RPO31 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014759.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2H5, P04051

UniProtKB/TrEMBL

A6ZNW4, C7GMM0, G2WMZ2, N1NYF1

Conserved Domains (3) summary

cd02736
Location:1077 → 1428

RNAP_III_Rpc1_C; Largest subunit (Rpc1) of Eukaryotic RNA polymerase III (RNAP III), C-terminal domain

PRK02597
Location:789 → 1114

rpoC2; DNA-directed RNA polymerase subunit beta'; Provisional

cd02583
Location:21 → 905

RNAP_III_RPC1_N; Largest subunit (RPC1) of eukaryotic RNA polymerase III (RNAP III), N-terminal domain