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RIO1 protein kinase RIO1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854286, updated on 18-Sep-2024

Summary

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Official Symbol
RIO1
Official Full Name
protein kinase RIO1
Primary source
SGD:S000005645
Locus tag
YOR119C
See related
AllianceGenome:SGD:S000005645; FungiDB:YOR119C; VEuPathDB:YOR119C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RRP10
Summary
Enables protein kinase activity. Involved in several processes, including maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); regulation of RNA metabolic process; and regulation of exit from mitosis. Located in cytoplasm and nucleolar chromatin. Orthologous to several human genes including RIOK1 (RIO kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RIO1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (548792..550246, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene proteasome regulatory particle base subunit RPT5 Neighboring gene Rtc5p Neighboring gene glycerol 2-dehydrogenase (NADP(+)) GCY1 Neighboring gene profilin

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast Rio1p is the founding member of a novel subfamily of protein serine kinases involved in the control of cell cycle progression. Angermayr M, et al. Mol Microbiol, 2002 Apr. PMID 11972772
  2. A nucleosome-free dG-dC-rich sequence element promotes constitutive transcription of the essential yeast RIO1 gene. Angermayr M, et al. Biol Chem, 2003 Sep. PMID 14515990
  3. The Link between Protein Kinase CK2 and Atypical Kinase Rio1. Kubiński K, et al. Pharmaceuticals (Basel), 2017 Feb 7. PMID 28178206, Free PMC Article
  4. RIO1, an extraordinary novel protein kinase. Angermayr M, et al. FEBS Lett, 2002 Jul 31. PMID 12135737
  5. The type of basal promoter determines the regulated or constitutive mode of transcription in the common control region of the yeast gene pair GCY1/RIO1. Angermayr M, et al. J Biol Chem, 1997 Dec 12. PMID 9395503

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The kinase Rio1 and a ribosome collision-dependent decay pathway survey the integrity of 18S rRNA cleavage.
    Title: The kinase Rio1 and a ribosome collision-dependent decay pathway survey the integrity of 18S rRNA cleavage.
  2. Rio1 downregulates centromeric RNA levels to promote the timely assembly of structurally fit kinetochores.
    Title: Rio1 downregulates centromeric RNA levels to promote the timely assembly of structurally fit kinetochores.
  3. Via its network, Rio1 commands protein synthesis (ribosomal gene expression, assembly and activity) and turnover (26S proteasome expression), and impinges on metabolic, energy-production and cell-cycle programs.
    Title: Integrating Rio1 activities discloses its nutrient-activated network in Saccharomyces cerevisiae.
  4. The study indicates that lack of Rio1p allows premature entry of pre-40S particles in the translation process.
    Title: The Rio1p ATPase hinders premature entry into translation of late pre-40S pre-ribosomal particles.
  5. Nuclear Rio1 promotes rDNA array stability and segregation.
    Title: Rio1 promotes rDNA stability and downregulates RNA polymerase I to ensure rDNA segregation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of exit from mitosis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of kinetochore assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolar chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of preribosome, small subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein kinase RIO1
NP_014762.3
  • Serine kinase that controls cell cycle progression; represses rDNA transcription and promotes 20S pre-rRNA maturation; catalytic activity regulates its association with pre-40S particles where it prevents premature entry into translation; downregulates centromeric RNA levels, limits RNAPII accessibility, stimulates cenRNA degradation and promotes timely kinetochore assembly; autophosphorylates and phosphorylates Rpa43p in anaphase to remove Pol I from rDNA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    548792..550246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183538.3 → NP_014762.3  TPA: protein kinase RIO1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014762.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2H8, Q00602, Q12196
    UniProtKB/TrEMBL
    A6ZNW7, B3LJG2, B5VS11, C7GML7, C8ZI81, G2WMZ5, N1NWZ0
    Conserved Domains (1) summary
    cd05147
    Location:78 → 291
    RIO1_euk; Catalytic domain of the atypical protein serine kinase, Eukaryotic RIO1 kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12196.1

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