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PFY1 profilin [ Saccharomyces cerevisiae S288C ]

Gene ID: 854289, updated on 2-Nov-2024

Summary

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Official Symbol
PFY1
Official Full Name
profilin
Primary source
SGD:S000005648
Locus tag
YOR122C
See related
AllianceGenome:SGD:S000005648; FungiDB:YOR122C; VEuPathDB:YOR122C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CLS5; PRF1
Summary
Enables actin monomer binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and proline-rich region binding activity. Involved in intracellular transport; mitotic actomyosin contractile ring assembly; and regulation of actin filament organization. Located in cytosol. Used to study amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 18. Orthologous to human PFN4 (profilin family member 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PFY1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
2
Sequence:
Chromosome: XV; NC_001147.6 (552298..552887, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene protein kinase RIO1 Neighboring gene glycerol 2-dehydrogenase (NADP(+)) GCY1 Neighboring gene Leo1p Neighboring gene ubiquitin-specific protease UBP2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hypoallergenic profilin--a new way to identify allergenic determinants. Paulus KE, et al. FEBS J, 2012 Aug. PMID 22682106
  2. Rational diversification of a promoter providing fine-tuned expression and orthogonal regulation for synthetic biology. Blount BA, et al. PLoS One, 2012. PMID 22442681, Free PMC Article
  3. The intron-containing gene for yeast profilin (PFY) encodes a vital function. Magdolen V, et al. Mol Cell Biol, 1988 Dec. PMID 3072473, Free PMC Article
  4. Regulation of profilin localization in Saccharomyces cerevisiae by phosphoinositide metabolism. Ostrander DB, et al. J Biol Chem, 1995 Nov 10. PMID 7592954
  5. Yeast profilin mutants inhibit classical nuclear import and alter the balance between actin and tubulin levels. Stochaj U. Biochem Cell Biol, 2024 Apr 1. PMID 38048555

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Profilin's Affinity for Formin Regulates the Availability of Filament Ends for Actin Monomer Binding.
    Title: Profilin's Affinity for Formin Regulates the Availability of Filament Ends for Actin Monomer Binding.
  2. The authors demonstrate that Pfy1 promotes actin polymerization under conditions of oxidative stress, while Pkc1 induces actin polymerization and cell survival under all the conditions tested.
    Title: Two proteins from Saccharomyces cerevisiae: Pfy1 and Pkc1, play a dual role in activating actin polymerization and in increasing cell viability in the adaptive response to oxidative stress.
  3. Profilin controls the energetics of its interaction with nonhybrid actin, but interactions between actin subdomains 1 and 2 affect the topography of the profilin binding site.
    Title: Control of the ability of profilin to bind and facilitate nucleotide exchange from G-actin.
  4. The mechanism and biological interaction of profilin and SRV2 protein were studied.
    Title: Mechanism and biological role of profilin-Srv2/CAP interaction.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin monomer binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin monomer binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin monomer binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables proline-rich region binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables proline-rich region binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic actomyosin contractile ring assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of formin-nucleated actin cable assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of formin-nucleated actin cable assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sequestering of actin monomers IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sequestering of actin monomers IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sequestering of actin monomers IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
profilin
NP_014765.3
  • Profilin; binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress; protein abundance increases in response to DNA replication stress; highly conserved protein; human PFN1 (profilin 1) complements temperature sensitive pfy1 mutants, PFN1 mutations are a rare cause of ALS

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    552298..552887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183541.3 → NP_014765.3  TPA: profilin [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014765.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2I0, P07274
    UniProtKB/TrEMBL
    A6ZNW9, B3LJG4, C8ZI84, G2WMZ7, N1NWL7
    Conserved Domains (1) summary
    pfam00235
    Location:1 → 123
    Profilin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07274.2

Gene LinkOut

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