LEO1 Leo1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: LEO1
Gene description: Leo1p
Primary source: FungiDB:YOR123C
Locus tag: YOR123C
See related: SGD:S000005649; AllianceGenome:SGD:S000005649; VEuPathDB:YOR123C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables several functions, including RNA polymerase II C-terminal domain phosphoserine binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and transcription coregulator activity. Involved in several processes, including histone H3-K4 trimethylation; positive regulation of DNA-templated transcription, elongation; and transcription, DNA-templated. Located in nucleus. Part of Cdc73/Paf1 complex. Orthologous to human LEO1 (LEO1 homolog, Paf1/RNA polymerase II complex component). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Leo1 subunit of the yeast paf1 complex binds RNA and contributes to complex recruitment
Title: Leo1 subunit of the yeast paf1 complex binds RNA and contributes to complex recruitment.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II C-terminal domain phosphoserine binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II C-terminal domain phosphoserine binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coregulator activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription termination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription elongation by RNA polymerase I	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription elongation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription elongation by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription-coupled nucleotide-excision repair	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sno(s)RNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription elongation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription elongation by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of Cdc73/Paf1 complex	IEA Inferred from Electronic Annotation more info
part_of Cdc73/Paf1 complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_014766.1

Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay