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EFT1 elongation factor 2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854301, updated on 18-Sep-2024

Summary

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Official Symbol
EFT1
Official Full Name
elongation factor 2
Primary source
SGD:S000005659
Locus tag
YOR133W
See related
AllianceGenome:SGD:S000005659; FungiDB:YOR133W; VEuPathDB:YOR133W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activity; chaperone binding activity; and ribosome binding activity. Involved in maintenance of translational fidelity; positive regulation of translational elongation; and translational elongation. Located in cytosol. Human ortholog(s) of this gene implicated in glaucoma and spinocerebellar ataxia type 26. Orthologous to human EEF2 (eukaryotic translation elongation factor 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See EFT1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (575098..577626)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene putative haloacid dehalogenase-like hydrolase Neighboring gene retromer subunit VPS17 Neighboring gene GTPase-activating protein BAG7 Neighboring gene isocitrate dehydrogenase (NAD(+)) IDH2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structures, Properties, and Dynamics of Intermediates in eEF2-Diphthamide Biosynthesis. Billod JM, et al. J Chem Inf Model, 2016 Sep 26. PMID 27525663
  2. Structural insights into the mechanism of translational inhibition by the fungicide sordarin. Chakraborty B, et al. J Comput Aided Mol Des, 2013 Feb. PMID 23397219
  3. Yeast as a tool for characterizing mono-ADP-ribosyltransferase toxins. Turgeon Z, et al. FEMS Microbiol Lett, 2009 Nov. PMID 19793133
  4. Importance of individual amino acids in the Switch I region in eEF2 studied by functional complementation in S. cerevisiae. Bartish G, et al. Biochimie, 2008 May. PMID 18267126
  5. Amino acids Thr56 and Thr58 are not essential for elongation factor 2 function in yeast. Bartish G, et al. FEBS J, 2007 Oct. PMID 17892487

See all (117) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-folding chaperone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in maintenance of translational fidelity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of translational elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 

General protein information

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Preferred Names
elongation factor 2
NP_014776.1
  • Elongation factor 2 (eEF2, EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    575098..577626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183552.1 → NP_014776.1  TPA: elongation factor 2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014776.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT19, P32324, Q6JEF7
    UniProtKB/TrEMBL
    A6ZNY0, B3LFR5, B5VGR2, C7GN88, C8Z5U9, G2WN08, N1P7B9
    Conserved Domains (1) summary
    PTZ00416
    Location:1 → 842
    PTZ00416; elongation factor 2; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32324.1

Gene LinkOut

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