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BAG7 GTPase-activating protein BAG7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854302, updated on 18-Sep-2024

Summary

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Official Symbol
BAG7
Official Full Name
GTPase-activating protein BAG7
Primary source
SGD:S000005660
Locus tag
YOR134W
See related
AllianceGenome:SGD:S000005660; FungiDB:YOR134W; VEuPathDB:YOR134W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activator activity. Involved in negative regulation of Rho protein signal transduction and positive regulation of GTPase activity. Predicted to be active in cell cortex. Orthologous to human GMIP (GEM interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See BAG7 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (578564..579793)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene retromer subunit VPS17 Neighboring gene elongation factor 2 Neighboring gene isocitrate dehydrogenase (NAD(+)) IDH2 Neighboring gene Sia1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The RHO1-GAPs SAC7, BEM2 and BAG7 control distinct RHO1 functions in Saccharomyces cerevisiae. Schmidt A, et al. Mol Microbiol, 2002 Sep. PMID 12207708
  2. Lrg1p functions as a putative GTPase-activating protein in the Pkc1p-mediated cell integrity pathway in Saccharomyces cerevisiae. Lorberg A, et al. Mol Genet Genomics, 2001 Nov. PMID 11713681
  3. Functional characterization of the Bag7, Lrg1 and Rgd2 RhoGAP proteins from Saccharomyces cerevisiae. Roumanie O, et al. FEBS Lett, 2001 Oct 5. PMID 11591390
  4. The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2. Schmidt A, et al. Cell, 1997 Feb 21. PMID 9038344
  5. Cadmium induces the activation of cell wall integrity pathway in budding yeast. Xiong B, et al. Chem Biol Interact, 2015 Oct 5. PMID 26362500

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of Rho protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of fungal-type cell wall organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
GTPase-activating protein BAG7
NP_014777.3
  • Rho GTPase activating protein (RhoGAP); stimulates the intrinsic GTPase activity of Rho1p, which plays a bud growth by regulating actin cytoskeleton organization and cell wall biosynthesis, resulting in the downregulation of Rho1p; structurally and functionally related to Sac7p; BAG7 has a paralog, SAC7, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    578564..579793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183553.3 → NP_014777.3  TPA: GTPase-activating protein BAG7 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014777.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2J2, Q12128
    UniProtKB/TrEMBL
    A6ZNY1, B3LJH6, B5VS23, C7GN87, C8ZI96, N1P368
    Conserved Domains (1) summary
    cd04396
    Location:47 → 257
    RhoGAP_fSAC7_BAG7; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12128.1

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