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Ddx52 DExD-box helicase 52 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85432, updated on 2-Nov-2024

Summary

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Official Symbol
Ddx52provided by RGD
Official Full Name
DExD-box helicase 52provided by RGD
Primary source
RGD:621743
See related
EnsemblRapid:ENSRNOG00000053814 AllianceGenome:RGD:621743
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rok1
Summary
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and RNA helicase activity. Predicted to be involved in maturation of SSU-rRNA. Predicted to be located in nucleolus. Orthologous to human DDX52 (DExD-box helicase 52). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 134.7), Spleen (RPKM 108.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ddx52 in Genome Data Viewer
Location:
10q26
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (69322062..69344856)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (68824594..68847400)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (71253667..71276397)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene HEAT repeat containing 6 Neighboring gene uncharacterized LOC134480708 Neighboring gene HNF1 homeobox B Neighboring gene uncharacterized LOC134480841 Neighboring gene synergin, gamma Neighboring gene uncharacterized LOC134480839

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Group II phospholipase A2 inhibitors suppressed lysophosphatidylserine-dependent degranulation of rat peritoneal mast cells. Murakami M, et al. Biochem Biophys Res Commun, 1991 Dec 16. PMID 1721808
  2. Rok1p is a putative RNA helicase required for rRNA processing. Venema J, et al. Mol Cell Biol, 1997 Jun. PMID 9154839, Free PMC Article
  3. Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10. Saad Y, et al. Genomics, 2007 Mar. PMID 17218081, Free PMC Article
  4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of SSU-rRNA IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable ATP-dependent RNA helicase DDX52
Names
ATP-dependent, RNA helicase
DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DEAD box protein 52
DEAD-box helicase 52
rROK1L
NP_445977.1
XP_038942927.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053525.1 → NP_445977.1  probable ATP-dependent RNA helicase DDX52

    See identical proteins and their annotated locations for NP_445977.1

    Status: PROVISIONAL

    Source sequence(s)
    AB055628
    UniProtKB/Swiss-Prot
    Q99PT0
    UniProtKB/TrEMBL
    A1EC69, A6HHJ6, Q5FWY7
    Related
    ENSRNOP00000003600.3, ENSRNOT00000003600.8
    Conserved Domains (3) summary
    PRK11192
    Location:163 → 591
    PRK11192; ATP-dependent RNA helicase SrmB; Provisional
    pfam00271
    Location:399 → 508
    Helicase_C; Helicase conserved C-terminal domain
    cl21455
    Location:170 → 376
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    69322062..69344856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086999.2 → XP_038942927.1  probable ATP-dependent RNA helicase DDX52 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GB03, A1EC69, Q5FWY7
    Related
    ENSRNOP00000083648.1, ENSRNOT00000119012.2
    Conserved Domains (2) summary
    COG0513
    Location:137 → 574
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd17957
    Location:177 → 378
    DEADc_DDX52; DEAD-box helicase domain of DEAD box protein 52
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99PT0.1 GenPept UniProtKB/Swiss-Prot:Q99PT0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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