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Smad9 SMAD family member 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85435, updated on 2-Nov-2024

Summary

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Symbol
Smad9provided by RGD
Full Name
SMAD family member 9provided by RGD
Primary source
RGD:71004
See related
EnsemblRapid:ENSRNOG00000000091 AllianceGenome:RGD:71004
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Madh9; Smad8
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including Mullerian duct regression; positive regulation of DNA-templated transcription; and response to hypoxia. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of heteromeric SMAD protein complex. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Orthologous to human SMAD9 (SMAD family member 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 33.8), Adrenal (RPKM 23.2) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Smad9 in Genome Data Viewer
Location:
2q26
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (141106668..141156477)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (138956326..139006315)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (143951725..144002025)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene SPT20 homolog, SAGA complex component Neighboring gene exosome component 8 Neighboring gene ALG5, dolichyl-phosphate beta-glucosyltransferase Neighboring gene uncharacterized LOC120100820 Neighboring gene regulatory factor X-associated protein Neighboring gene uncharacterized LOC134485734

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Smad8 mediates the signaling of the ALK-2 [corrected] receptor serine kinase. Chen Y, et al. Proc Natl Acad Sci U S A, 1997 Nov 25. PMID 9371779, Free PMC Article
  2. Neotendon formation induced by manipulation of the Smad8 signalling pathway in mesenchymal stem cells. Hoffmann A, et al. J Clin Invest, 2006 Apr. PMID 16585960, Free PMC Article
  3. Hypoxia induces alteration of bone morphogenetic protein receptor signaling in pulmonary artery endothelial cell. Takahashi K, et al. Pediatr Res, 2007 Apr. PMID 17515860
  4. Biomechanical forces exert anabolic effects on osteoblasts by activation of SMAD 1/5/8 through type 1 BMP receptor. Rath B, et al. Biorheology, 2011. PMID 21515935, Free PMC Article
  5. Müllerian inhibiting substance regulates its receptor/SMAD signaling and causes mesenchymal transition of the coelomic epithelial cells early in Müllerian duct regression. Zhan Y, et al. Development, 2006 Jun. PMID 16687449

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cpd 861 markedly upregulated the gene expression of BMP7 and Smad5, as well as the protein expression of BMP7 and Smad1/5. In addition, p-Smad1/5/8 protein expression was markedly increased by Cpd 861 in the liver fibrosis model.
    Title: Attenuation of liver fibrosis by herbal compound 861 via upregulation of BMP-7/Smad signaling in the bile duct ligation model rat.
  2. Taken together, these results indicated that FSTL1 protects the SNP-induced injury in cardiac H9c2 cells through, at least in part, the activation of Akt and inhibition of Smad1/5/9 signaling.
    Title: Follistatin-like 1 protects cardiomyoblasts from injury induced by sodium nitroprusside through modulating Akt and Smad1/5/9 signaling.
  3. biomechanical stimulation of osteoblasts activates SMAD 1/5/8 in the BMP signaling pathway through BMPR1 and may enhance osteogenesis by upregulating SMAD-dependent osteogenic genes
    Title: Biomechanical forces exert anabolic effects on osteoblasts by activation of SMAD 1/5/8 through type 1 BMP receptor.
  4. Expression of BMP receptors Ib and II, and Smad 8 was downregulated in lungs but not kidneys of MCT-treated rats.
    Title: Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension.
  5. Data suggest that Mullerian inhibiting substance (MIS) initiates an epithelial-to-mesenchymal transition of MIS receptor-expressing cells and specifies the components of the receptor/SMAD8 signaling pathway by regulating their expression.
    Title: Müllerian inhibiting substance regulates its receptor/SMAD signaling and causes mesenchymal transition of the coelomic epithelial cells early in Müllerian duct regression.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables I-SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in Mullerian duct regression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in bone development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within bone development ISO
Inferred from Sequence Orthology
more info
  
involved_in cartilage development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cartilage development ISO
Inferred from Sequence Orthology
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
  
involved_in hindbrain development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hindbrain development ISO
Inferred from Sequence Orthology
more info
  
involved_in midbrain development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within midbrain development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ureteric bud development IEA
Inferred from Electronic Annotation
more info
  
involved_in ureteric bud development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of heteromeric SMAD protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mothers against decapentaplegic homolog 9
Names
MAD homolog 9
SMAD 9
mothers against DPP homolog 9
NP_620227.2
XP_063138716.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138872.2 → NP_620227.2  mothers against decapentaplegic homolog 9

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    O54835
    UniProtKB/TrEMBL
    A6JVE0, G3V603
    Related
    ENSRNOP00000000102.1, ENSRNOT00000000102.5
    Conserved Domains (2) summary
    cd10490
    Location:13 → 136
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cl00056
    Location:230 → 430
    MH2; C-terminal Mad Homology 2 (MH2) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    141106668..141156477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282646.1 → XP_063138716.1  mothers against decapentaplegic homolog 9 isoform X1

    UniProtKB/TrEMBL
    A6JVE0, G3V603
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54835.1 GenPept UniProtKB/Swiss-Prot:O54835

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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