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GSP2 Ran GTPase GSP2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854357, updated on 18-Sep-2024

Summary

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Official Symbol
GSP2
Official Full Name
Ran GTPase GSP2
Primary source
SGD:S000005711
Locus tag
YOR185C
See related
AllianceGenome:SGD:S000005711; FungiDB:YOR185C; VEuPathDB:YOR185C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CNR2
Summary
Predicted to enable GTPase activity. Involved in nucleus organization. Located in nucleus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human RAN (RAN, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See GSP2 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (681444..682106, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene O-phospho-L-serine:2-oxoglutarate transaminase Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene translation elongation factor Tu

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A gene from Saccharomyces cerevisiae which codes for a protein with significant homology to the bacterial 3-phosphoserine aminotransferase. Belhumeur P, et al. Yeast, 1994 Mar. PMID 8017107
  2. The GTP-bound form of the yeast Ran/TC4 homologue blocks nuclear protein import and appearance of poly(A)+ RNA in the cytoplasm. Schlenstedt G, et al. Proc Natl Acad Sci U S A, 1995 Jan 3. PMID 7816822, Free PMC Article
  3. Analysis of the molecular basis of Saccharomyces cerevisiae mutant with high nucleic acid content by comparative transcriptomics. Guo X, et al. Food Res Int, 2021 Apr. PMID 33773664
  4. Role of the nuclear transport factor p10 in nuclear import. Nehrbass U, et al. Science, 1996 Apr 5. PMID 8600522
  5. GSP1 and GSP2, genetic suppressors of the prp20-1 mutant in Saccharomyces cerevisiae: GTP-binding proteins involved in the maintenance of nuclear organization. Belhumeur P, et al. Mol Cell Biol, 1993 Apr. PMID 8455603, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
involved_in nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleus organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in poly(A)+ mRNA export from nucleus ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISA
Inferred from Sequence Alignment
more info
 PubMed 

General protein information

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Preferred Names
Ran GTPase GSP2
NP_014828.1
  • GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); not required for viability; protein abundance increases in response to DNA replication stress; GSP2 has a paralog, GSP1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    681444..682106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183604.1 → NP_014828.1  TPA: Ran GTPase GSP2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014828.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2P1, P32836
    UniProtKB/TrEMBL
    A6ZP30, B3LJL5, B5VS69, C7GLQ9, C8ZGU4, G2WN58, N1NVU4
    Conserved Domains (1) summary
    PTZ00132
    Location:5 → 217
    PTZ00132; GTP-binding nuclear protein Ran; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32836.1

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