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IES4 Ies4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854361, updated on 2-Nov-2024

Summary

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Official Symbol
IES4
Official Full Name
Ies4p
Primary source
SGD:S000005715
Locus tag
YOR189W
See related
AllianceGenome:SGD:S000005715; FungiDB:YOR189W; VEuPathDB:YOR189W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in DNA damage response and telomere maintenance via recombination. Located in nucleus. Part of Ino80 complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See IES4 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (689624..689974)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene translation elongation factor Tu Neighboring gene Msb1p Neighboring gene glucan 1,3-beta-glucosidase Neighboring gene translocase ULS1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphorylation-Dependent Enhancement of Rad53 Kinase Activity through the INO80 Chromatin Remodeling Complex. Kapoor P, et al. Mol Cell, 2015 Jun 4. PMID 25959398, Free PMC Article
  2. The INO80 Complex Requires the Arp5-Ies6 Subcomplex for Chromatin Remodeling and Metabolic Regulation. Yao W, et al. Mol Cell Biol, 2016 Jan 11. PMID 26755556, Free PMC Article
  3. Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates. Hauer MH, et al. Nat Struct Mol Biol, 2017 Feb. PMID 28067915
  4. Identification of Topological Network Modules in Perturbed Protein Interaction Networks. Sardiu ME, et al. Sci Rep, 2017 Mar 8. PMID 28272416, Free PMC Article
  5. Structure and functional interactions of INO80 actin/Arp module. Zhang X, et al. J Mol Cell Biol, 2019 May 1. PMID 30388237, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Ies4 subunit of the INO80 complex is a functional component in the Mec1/Tel1 DNA damage signaling pathway that modulates checkpoint responses.
    Title: Mec1/Tel1 phosphorylation of the INO80 chromatin remodeling complex influences DNA damage checkpoint responses.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance via recombination IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of Ino80 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Ino80 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ies4p
NP_014832.1
  • Component of the INO80 chromatiin remodeling complex; target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    689624..689974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183608.1 → NP_014832.1  TPA: Ies4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014832.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2P5, Q08561
    UniProtKB/TrEMBL
    A6ZP34, B3LJL9, C7GLQ5, C8ZGU9, G2WN62, N1NVU6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08561.1

Gene LinkOut

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