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NOC2 mRNA-binding ribosome synthesis protein NOC2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854381, updated on 18-Sep-2024

Summary

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Official Symbol
NOC2
Official Full Name
mRNA-binding ribosome synthesis protein NOC2
Primary source
SGD:S000005732
Locus tag
YOR206W
See related
AllianceGenome:SGD:S000005732; FungiDB:YOR206W; VEuPathDB:YOR206W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mRNA binding activity. Involved in ribosomal large subunit biogenesis. Located in nucleoplasm. Part of Noc1p-Noc2p complex and Noc2p-Noc3p complex. Orthologous to human NOC2L (NOC2 like nucleolar associated transcriptional repressor). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See NOC2 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (727512..729644)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene DEAD-box ATP-dependent RNA helicase DED1 Neighboring gene Gep3p Neighboring gene DNA-directed RNA polymerase III core subunit RET1 Neighboring gene tyrosine protein phosphatase PTP2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Coevolution of ribosomal RNA expansion segment 7L and assembly factor Noc2p specializes the ribosome biogenesis pathway between Saccharomyces cerevisiae and Candida albicans. Wang X, et al. Nucleic Acids Res, 2021 May 7. PMID 33823547, Free PMC Article
  2. Maturation and intranuclear transport of pre-ribosomes requires Noc proteins. Milkereit P, et al. Cell, 2001 May 18. PMID 11371346
  3. Rrp5 establishes a checkpoint for 60S assembly during 40S maturation. Khoshnevis S, et al. RNA, 2019 Sep. PMID 31217256, Free PMC Article
  4. Sen34p depletion blocks tRNA splicing in vivo and delays rRNA processing. Volta V, et al. Biochem Biophys Res Commun, 2005 Nov 11. PMID 16188229
  5. The Noc proteins involved in ribosome synthesis and export contain divergent HEAT repeats. Dlakić M, et al. RNA, 2004 Mar. PMID 14970380, Free PMC Article

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Coevolution of ribosomal RNA expansion segment 7L and assembly factor Noc2p specializes the ribosome biogenesis pathway between Saccharomyces cerevisiae and Candida albicans.
    Title: Coevolution of ribosomal RNA expansion segment 7L and assembly factor Noc2p specializes the ribosome biogenesis pathway between Saccharomyces cerevisiae and Candida albicans.
  2. The results show that the large ribosomal subunit (LSU) biogenesis factor Noc1p of Saccharomyces cerevisiae can simultaneously interact with the LSU biogenesis factor Noc2p and Rrp5p.
    Title: Rrp5p, Noc1p and Noc2p form a protein module which is part of early large ribosomal subunit precursors in S. cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables mRNA binding HDA PubMed 
Process Evidence Code Pubs
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Noc1p-Noc2p complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Noc1p-Noc2p complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Noc2p-Noc3p complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Noc2p-Noc3p complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mRNA-binding ribosome synthesis protein NOC2
NP_014849.3
  • Protein involved in ribosome biogenesis; forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes; forms a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    727512..729644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183625.3 → NP_014849.3  TPA: mRNA-binding ribosome synthesis protein NOC2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014849.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2R2, P39744, Q08625
    UniProtKB/TrEMBL
    A6ZP49, B3LJN1, B5VS88, C8ZGW2, N1P3F0
    Conserved Domains (1) summary
    COG5604
    Location:1 → 664
    COG5604; Uncharacterized conserved protein [Function unknown]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39744.2

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