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STE13 Ste13p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854394, updated on 17-May-2024

Summary

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Gene symbol
STE13
Gene description
Ste13p
Primary source
FungiDB:YOR219C
Locus tag
YOR219C
See related
SGD:S000005745; AllianceGenome:SGD:S000005745; VEuPathDB:YOR219C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YCI1
Summary
Enables aminopeptidase activity. Involved in peptide pheromone maturation. Located in trans-Golgi network. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; asthma; autosomal dominant non-syndromic intellectual disability 33; and spinal muscular atrophy. Orthologous to human DPP10 (dipeptidyl peptidase like 10); DPP6 (dipeptidyl peptidase like 6); and FAP (fibroblast activation protein alpha). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See STE13 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (752214..755009, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Rud3p Neighboring gene replication factor C subunit 1 Neighboring gene Rcn2p Neighboring gene [acyl-carrier-protein] S-malonyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and DNA sequence of the STE13 gene encoding dipeptidyl aminopeptidase. Anna-Arriola SS, et al. Yeast, 1994 Jun. PMID 7975897
  2. Ultracytochemical evidence of Golgi functions in microvesicles at all phases of cell cycle in Saccharomyces cerevisiae. Vorísek J. Micron, 1995. PMID 7767635
  3. Yeast peptide pheromones, a-factor and alpha-factor, activate a common response mechanism in their target cells. Bender A, et al. Cell, 1986 Dec 26. PMID 3022943
  4. Cell-free reconstitution of transport from the trans-golgi network to the late endosome/prevacuolar compartment. Blanchette JM, et al. J Biol Chem, 2004 Nov 19. PMID 15364946
  5. Two separate signals act independently to localize a yeast late Golgi membrane protein through a combination of retrieval and retention. Bryant NJ, et al. J Cell Biol, 1997 Jan 27. PMID 9015300, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. S13 phosphorylation is required for trans-Golgi network-to-prevacuolar compartment trafficking of A-alkaline phosphatase
    Title: Golgi-to-late endosome trafficking of the yeast pheromone processing enzyme Ste13p is regulated by a phosphorylation site in its cytosolic domain.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables aminopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables dipeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptide pheromone maturation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptide pheromone maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in response to pheromone IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ste13p
NP_014862.3
  • Dipeptidyl aminopeptidase; Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    752214..755009 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183638.3 → NP_014862.3  TPA: Ste13p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014862.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2S4, P33894, Q9URF1
    UniProtKB/TrEMBL
    A0A8H4BV22, B3LJP2, B5VSA1, C7GWG4, C8ZGX3, N1NWT2
    Conserved Domains (2) summary
    COG1506
    Location:359 → 922
    DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
    pfam00930
    Location:247 → 623
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33894.1

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