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MCP1 Mcp1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854403, updated on 18-Sep-2024

Summary

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Official Symbol
MCP1
Official Full Name
Mcp1p
Primary source
SGD:S000005754
Locus tag
YOR228C
See related
AllianceGenome:SGD:S000005754; FungiDB:YOR228C; VEuPathDB:YOR228C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in lipid homeostasis and mitochondrion organization. Located in mitochondrial outer membrane. Is integral component of mitochondrial membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MCP1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (766869..767777, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene putative iron-binding protein ISU2 Neighboring gene Her1p Neighboring gene transcriptional modulator Neighboring gene transcriptional modulator

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ER-mitochondria contacts promote mitochondrial-derived compartment biogenesis. English AM, et al. J Cell Biol, 2020 Dec 7. PMID 33090183, Free PMC Article
  2. Vps13-Mcp1 interact at vacuole-mitochondria interfaces and bypass ER-mitochondria contact sites. John Peter AT, et al. J Cell Biol, 2017 Oct 2. PMID 28864540, Free PMC Article
  3. The GTPase Arf1 Is a Determinant of Yeast Vps13 Localization to the Golgi Apparatus. Kolakowski D, et al. Int J Mol Sci, 2021 Nov 12. PMID 34830155, Free PMC Article
  4. Competitive organelle-specific adaptors recruit Vps13 to membrane contact sites. Bean BDM, et al. J Cell Biol, 2018 Oct 1. PMID 30018089, Free PMC Article
  5. A VPS13D spastic ataxia mutation disrupts the conserved adaptor-binding site in yeast Vps13. Dziurdzik SK, et al. Hum Mol Genet, 2020 Mar 13. PMID 31943017, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane HDA PubMed 
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mcp1p
NP_014871.3
  • Mitochondrial hypothetical protein involved in lipid homeostasis; integral membrane protein that localizes to the mitochondrial outer membrane; involved in mitochondrial morphology; interacts genetically with MDM10, and other members of the ERMES complex; contains five predicted transmembrane domains

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    766869..767777 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183647.3 → NP_014871.3  TPA: Mcp1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014871.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2T2, Q12106
    UniProtKB/TrEMBL
    A6ZP69, B3LJQ0, C7GWF6, C8ZGY1, N1NYP6
    Conserved Domains (1) summary
    pfam07950
    Location:182 → 278
    DUF1691; Protein of unknown function (DUF1691)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12106.1

Gene LinkOut

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