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HES1 oxysterol-binding protein related protein HES1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854412, updated on 18-Sep-2024

Summary

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Official Symbol
HES1
Official Full Name
oxysterol-binding protein related protein HES1
Primary source
SGD:S000005763
Locus tag
YOR237W
See related
AllianceGenome:SGD:S000005763; FungiDB:YOR237W; VEuPathDB:YOR237W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
OSH5
Summary
Enables oxysterol binding activity and sterol transfer activity. Involved in several processes, including maintenance of cell polarity; piecemeal microautophagy of the nucleus; and sterol transport. Located in cellular bud neck and fungal-type vacuole membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See HES1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (781994..783298)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Irc13p Neighboring gene ncRNA Neighboring gene dihydrofolate reductase Neighboring gene uncharacterized protein Neighboring gene tRNA(Thr) (cytosine(32)-N(3))-methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sterol binding assay using surface plasmon fluorescence spectroscopy. Wiltschi B, et al. Anal Chem, 2006 Jan 15. PMID 16408938
  2. A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein. Jiang B, et al. Yeast, 1994 Mar. PMID 8017104
  3. Osh6 overexpression extends the lifespan of yeast by increasing vacuole fusion. Gebre S, et al. Cell Cycle, 2012 Jun 1. PMID 22622083
  4. Oxysterol-binding protein homologs mediate sterol transport from the endoplasmic reticulum to mitochondria in yeast. Tian S, et al. J Biol Chem, 2018 Apr 13. PMID 29487131, Free PMC Article
  5. Osh proteins regulate membrane sterol organization but are not required for sterol movement between the ER and PM. Georgiev AG, et al. Traffic, 2011 Oct. PMID 21689253, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Coordinated regulation of phosphatidylinositol 4-phosphate and phosphatidylserine levels by Osh4p and Osh5p is an essential regulatory mechanism in autophagy.
    Title: Coordinated regulation of phosphatidylinositol 4-phosphate and phosphatidylserine levels by Osh4p and Osh5p is an essential regulatory mechanism in autophagy.
  2. Osh5-Osh7 bind cholesterol in vitro.
    Title: Oxysterol-binding protein homologs mediate sterol transport from the endoplasmic reticulum to mitochondria in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables lipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables oxysterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxysterol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxysterol binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables sterol transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sterol transfer activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in exocytosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in maintenance of cell polarity IEA
Inferred from Electronic Annotation
more info
  
involved_in maintenance of cell polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in piecemeal microautophagy of the nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in piecemeal microautophagy of the nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sterol transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sterol transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sterol transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
oxysterol-binding protein related protein HES1
NP_014880.3
  • Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP); SWAT-GFP and mCherry fusion proteins localize to the bud neck and vacuolar membrane; HES1 has a paralog, KES1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    781994..783298
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183656.3 → NP_014880.3  TPA: oxysterol-binding protein related protein HES1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014880.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2U0, P35843
    UniProtKB/TrEMBL
    B3LJQ8, C7GWE9, N1NX89
    Conserved Domains (1) summary
    pfam01237
    Location:12 → 365
    Oxysterol_BP; Oxysterol-binding protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35843.1

Gene LinkOut

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