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DCLK3 doublecortin like kinase 3 [ Homo sapiens (human) ]

Gene ID: 85443, updated on 5-Mar-2024

Summary

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Official Symbol
DCLK3provided by HGNC
Official Full Name
doublecortin like kinase 3provided by HGNC
Primary source
HGNC:HGNC:19005
See related
Ensembl:ENSG00000163673 MIM:613167; AllianceGenome:HGNC:19005
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLR; DCK3; DCDC3C; DCAMKL3
Summary
Predicted to enable protein kinase activity. Predicted to be involved in peptidyl-serine phosphorylation. Predicted to act upstream of or within negative regulation of protein localization to nucleus. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 2.2), brain (RPKM 0.5) and 6 other tissues See more
Orthologs
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Genomic context

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Location:
3p22.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (36712421..36764553, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (36713774..36765897, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (36753912..36806044, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene NBPF member 21, pseudogene Neighboring gene RN7SK pseudogene 227 Neighboring gene NANOG hESC enhancer GRCh37_chr3:36739560-36740214 Neighboring gene Sharpr-MPRA regulatory region 13437 Neighboring gene uncharacterized LOC105377029 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A diagnostic marker set for invasion, proliferation, and aggressiveness of prolactin pituitary tumors. Wierinckx A, et al. Endocr Relat Cancer, 2007 Sep. PMID 17914117
  2. Bacterial expression and purification of a heterodimeric adrenomedullin receptor extracellular domain complex using DsbC-assisted disulfide shuffling. Hill HE, et al. Protein Expr Purif, 2013 Mar. PMID 23247088, Free PMC Article
  3. Refolding and characterization of a soluble ectodomain complex of the calcitonin gene-related peptide receptor. Koth CM, et al. Biochemistry, 2010 Mar 9. PMID 20099900
  4. Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV. Ohmae S, et al. J Biol Chem, 2006 Jul 21. PMID 16684769
  5. The doublecortin gene family and disorders of neuronal structure. Dijkmans TF, et al. Cent Nerv Syst Agents Med Chem, 2010 Mar. PMID 20236041

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1765

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase DCLK3
Names
CLICK-I,II-related
doublecortin and CaM kinase-like 3
doublecortin domain-containing protein 3C
doublecortin-like and CAM kinase-like 3
NP_001381601.1
NP_208382.1
XP_047305046.1
XP_054204134.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394672.2 → NP_001381601.1  serine/threonine-protein kinase DCLK3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC105749
    Consensus CDS
    CCDS93239.1
    UniProtKB/TrEMBL
    A0A1B0GTZ4
    Related
    ENSP00000489900.1, ENST00000636136.2
    Conserved Domains (2) summary
    cd14185
    Location:524 → 781
    STKc_DCKL3; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 3 (also called Doublecortin-like and CAM kinase-like 3)
    cd16111
    Location:93 → 177
    DCX_DCLK3; Doublecortin-like domain found in doublecortin-like kinase 3 (DCLK3)

  2. NM_033403.1 → NP_208382.1  serine/threonine-protein kinase DCLK3 isoform 2

    See identical proteins and their annotated locations for NP_208382.1

    Status: VALIDATED

    Source sequence(s)
    AB051552, AC105749, AK122988, DB075681, DR000236
    Consensus CDS
    CCDS43064.1
    UniProtKB/Swiss-Prot
    Q9C098
    UniProtKB/TrEMBL
    B3KVM3
    Related
    ENSP00000394484.2, ENST00000416516.2
    Conserved Domains (2) summary
    smart00220
    Location:356 → 613
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14185
    Location:355 → 612
    STKc_DCKL3; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 3 (also called Doublecortin-like and CAM kinase-like 3)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    36712421..36764553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449090.1 → XP_047305046.1  serine/threonine-protein kinase DCLK3 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    36713774..36765897 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348159.1 → XP_054204134.1  serine/threonine-protein kinase DCLK3 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C098.2 GenPept UniProtKB/Swiss-Prot:Q9C098

Gene LinkOut

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