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GCD1 translation initiation factor eIF2B subunit gamma [ Saccharomyces cerevisiae S288C ]

Gene ID: 854434, updated on 2-Nov-2024

Summary

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Official Symbol
GCD1
Official Full Name
translation initiation factor eIF2B subunit gamma
Primary source
SGD:S000005786
Locus tag
YOR260W
See related
AllianceGenome:SGD:S000005786; FungiDB:YOR260W; VEuPathDB:YOR260W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
TRA3
Summary
Enables translation initiation factor activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in negative regulation of cellular response to amino acid starvation and regulation of translational initiation. Located in cytosol. Part of eukaryotic translation initiation factor 2B complex and guanyl-nucleotide exchange factor complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 3. Orthologous to human EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See GCD1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (813984..815720)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene DNA 5'-adenosine monophosphate hydrolase Neighboring gene proteasome regulatory particle base subunit RPT4 Neighboring gene proteasome regulatory particle lid subunit RPN8 Neighboring gene putative GTPase GPN2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Integration of amino acid biosynthesis into the cell cycle of Saccharomyces cerevisiae. Wolfner M, et al. J Mol Biol, 1975 Aug 5. PMID 1100845
  2. A novel eIF2B-dependent mechanism of translational control in yeast as a response to fusel alcohols. Ashe MP, et al. EMBO J, 2001 Nov 15. PMID 11707417, Free PMC Article
  3. Molecular characterization of GCD1, a yeast gene required for general control of amino acid biosynthesis and cell-cycle initiation. Hill DE, et al. Nucleic Acids Res, 1988 Oct 11. PMID 3050897, Free PMC Article
  4. A rapid method for determining tRNA charging levels in vivo: analysis of yeast mutants defective in the general control of amino acid biosynthesis. Hill DE, et al. Nucleic Acids Res, 1986 Dec 22. PMID 3543839, Free PMC Article
  5. Multiple upstream AUG codons mediate translational control of GCN4. Mueller PP, et al. Cell, 1986 Apr 25. PMID 3516411

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data show that multiple contacts between eIF2gamma and eIF2Bepsilon mediate nucleotide exchange.
    Title: Critical contacts between the eukaryotic initiation factor 2B (eIF2B) catalytic domain and both eIF2beta and -2gamma mediate guanine nucleotide exchange.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to guanyl-nucleotide exchange factor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables translation initiation factor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cellular response to amino acid starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of translational initiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of translational initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 2B complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 2B complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of guanyl-nucleotide exchange factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of guanyl-nucleotide exchange factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of guanyl-nucleotide exchange factor complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
translation initiation factor eIF2B subunit gamma
NP_014903.1
  • Gamma subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    813984..815720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183679.1 → NP_014903.1  TPA: translation initiation factor eIF2B subunit gamma [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014903.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2W1, P09032, Q08721
    UniProtKB/TrEMBL
    A6ZP98, B3LJS8, B5VSE1, C7GWC9, C8ZH11, N1NVX3
    Conserved Domains (2) summary
    cd04652
    Location:433 → 513
    LbH_eIF2B_gamma_C; eIF-2B gamma subunit, C-terminal Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is ...
    cd04198
    Location:3 → 285
    eIF-2B_gamma_N; The N-terminal domain of gamma subunit of the eIF-2B is a subfamily of glycosyltransferase 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09032.3

Gene LinkOut

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