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PNT1 Pnt1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854440, updated on 18-Sep-2024

Summary

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Official Symbol
PNT1
Official Full Name
Pnt1p
Primary source
SGD:S000005792
Locus tag
YOR266W
See related
AllianceGenome:SGD:S000005792; FungiDB:YOR266W; VEuPathDB:YOR266W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in protein insertion into mitochondrial inner membrane from matrix. Is integral component of mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PNT1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (821023..822294)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Dse3p Neighboring gene Rbl2p Neighboring gene putative serine/threonine protein kinase HRK1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations affecting a yeast mitochondrial inner membrane protein, pnt1p, block export of a mitochondrially synthesized fusion protein from the matrix. He S, et al. Mol Cell Biol, 1999 Oct. PMID 10490599, Free PMC Article
  2. Characterization of the PNT1 pentamidine resistance gene of Saccharomyces cerevisiae. Ludewig G, et al. Antimicrob Agents Chemother, 1994 Dec. PMID 7695273, Free PMC Article
  3. Cox18p is required for export of the mitochondrially encoded Saccharomyces cerevisiae Cox2p C-tail and interacts with Pnt1p and Mss2p in the inner membrane. Saracco SA, et al. Mol Biol Cell, 2002 Apr. PMID 11950926, Free PMC Article
  4. Spatial orchestration of mitochondrial translation and OXPHOS complex assembly. Stoldt S, et al. Nat Cell Biol, 2018 May. PMID 29662179
  5. Yeast Saccharomyces cerevisiae adiponectin receptor homolog Izh2 is involved in the regulation of zinc, phospholipid and pH homeostasis. Mattiazzi Ušaj M, et al. Metallomics, 2015 Sep. PMID 26067383

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein insertion into mitochondrial inner membrane from matrix IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein insertion into mitochondrial inner membrane from matrix IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein insertion into mitochondrial inner membrane from matrix IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in response to antibiotic IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pnt1p
NP_014909.3
  • Mitochondrial integral inner membrane protein; involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    821023..822294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183685.3 → NP_014909.3  TPA: Pnt1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014909.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2W6, P38969, Q08730
    UniProtKB/TrEMBL
    G2WND3, N1P3L4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38969.2

Gene LinkOut

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