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FSF1 Fsf1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854445, updated on 18-Sep-2024

Summary

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Official Symbol
FSF1
Official Full Name
Fsf1p
Primary source
SGD:S000005797
Locus tag
YOR271C
See related
AllianceGenome:SGD:S000005797; FungiDB:YOR271C; VEuPathDB:YOR271C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in mitochondrial transmembrane transport. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 18. Orthologous to several human genes including SFXN5 (sideroflexin 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See FSF1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (831059..832042, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Pac1p Neighboring gene H(+)-transporting V0 sector ATPase subunit a Neighboring gene ncRNA Neighboring gene Ytm1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In silico analyses of Fsf1 sequences, a new group of fungal proteins orthologous to the metazoan sideroblastic anemia-related sideroflexin family. Miotto G, et al. Fungal Genet Biol, 2007 Aug. PMID 17240176
  2. Comparative genomics of transcriptional regulation in yeasts and its application to identification of a candidate alpha-isopropylmalate transporter. Kovaleva GY, et al. J Bioinform Comput Biol, 2006 Oct. PMID 17099937
  3. A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism. Enriquez-Hesles E, et al. J Biol Chem, 2021 Jan-Jun. PMID 33243834, Free PMC Article
  4. A large-scale overexpression screen in Saccharomyces cerevisiae identifies previously uncharacterized cell cycle genes. Stevenson LF, et al. Proc Natl Acad Sci U S A, 2001 Mar 27. PMID 11274415, Free PMC Article
  5. Cardiolipin defines the interactome of the major ADP/ATP carrier protein of the mitochondrial inner membrane. Claypool SM, et al. J Cell Biol, 2008 Sep 8. PMID 18779372, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables monoatomic ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in L-serine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to anoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Fsf1p
NP_014914.1
  • Putative protein; predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    831059..832042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183690.1 → NP_014914.1  TPA: Fsf1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014914.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2X1, Q12029
    UniProtKB/TrEMBL
    A6ZPA8, B3LJT7, B5VSF0, C7GWB9, C8ZH21, G2WND9, N1NVX7
    Conserved Domains (1) summary
    pfam03820
    Location:10 → 327
    Mtc; Tricarboxylate carrier
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12029.1

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