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CPA1 carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854479, updated on 2-Nov-2024

Summary

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Official Symbol
CPA1
Official Full Name
carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1
Primary source
SGD:S000005829
Locus tag
YOR303W
See related
AllianceGenome:SGD:S000005829; FungiDB:YOR303W; VEuPathDB:YOR303W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity. Involved in L-arginine biosynthetic process. Located in cytoplasmic stress granule. Part of carbamoyl-phosphate synthase complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CPA1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (882899..884134)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Rax1p Neighboring gene uncharacterized protein Neighboring gene DNA translocase Neighboring gene Bil1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nucleotide sequence of yeast gene CP A1 encoding the small subunit of arginine-pathway carbamoyl-phosphate synthetase. Homology of the deduced amino acid sequence to other glutamine amidotransferases. Werner M, et al. Eur J Biochem, 1985 Jan 15. PMID 3881260
  2. Evolutionarily conserved features of the arginine attenuator peptide provide the necessary requirements for its function in translational regulation. Fang P, et al. J Biol Chem, 2000 Sep 1. PMID 10818103
  3. The leader peptide of yeast gene CPA1 is essential for the translational repression of its expression. Werner M, et al. Cell, 1987 Jun 19. PMID 3555844
  4. The biosynthesis of carbamoyl phosphate in Saccharomyces cerevisiae. Lacroute F, et al. J Gen Microbiol, 1965 Jul. PMID 5856369
  5. In vivo mutational analysis of highly conserved amino acid residues of the small subunit Cpa1p of the carbamylphosphate synthetase of Saccharomyces cerevisiae. Bernard A, et al. Yeast, 1997 Sep 15. PMID 9290206

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glutaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-arginine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-arginine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-arginine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glutamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of carbamoyl-phosphate synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of carbamoyl-phosphate synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule HDA PubMed 

General protein information

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Preferred Names
carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1
NP_014947.3
  • Small subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    882899..884134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183722.3 → NP_014947.3  TPA: carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014947.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W302, P07258
    UniProtKB/TrEMBL
    A6ZPD8, C7GNV8, C8ZH53, G2WNG9, N1NWY7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07258.1

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