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SNU66 U4/U6-U5 snRNP complex subunit SNU66 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854485, updated on 2-Nov-2024

Summary

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Official Symbol
SNU66
Official Full Name
U4/U6-U5 snRNP complex subunit SNU66
Primary source
SGD:S000005835
Locus tag
YOR308C
See related
AllianceGenome:SGD:S000005835; FungiDB:YOR308C; VEuPathDB:YOR308C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in mRNA splicing, via spliceosome and maturation of 5S rRNA. Part of U4/U6 x U5 tri-snRNP complex. Orthologous to human SART1 (spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SNU66 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (894624..896387, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene riboflavin transporter Neighboring gene Sly41p Neighboring gene RNA-processing protein NOP58 Neighboring gene diacylglycerol kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide identification of genes involved in growth and fermentation activity at low temperature in Saccharomyces cerevisiae. Salvadó Z, et al. Int J Food Microbiol, 2016 Nov 7. PMID 27442849
  2. LSM1 over-expression in Saccharomyces cerevisiae depletes U6 snRNA levels. Luhtala N, et al. Nucleic Acids Res, 2009 Sep. PMID 19596813, Free PMC Article
  3. Broader roles of the ubiquitin-like protein Hub1 indicated by its yeast two-hybrid interactors. Varikkapulakkal A, et al. MicroPubl Biol, 2022. PMID 35098049, Free PMC Article
  4. Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast. Wilkinson CR, et al. Curr Biol, 2004 Dec 29. PMID 15620657
  5. A single SR-like protein, Npl3, promotes pre-mRNA splicing in budding yeast. Kress TL, et al. Mol Cell, 2008 Dec 5. PMID 19061647, Free PMC Article

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA cis splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maturation of 5S rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of 5S rRNA IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in maturation of 5S rRNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U4/U6 x U5 tri-snRNP complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U4/U6 x U5 tri-snRNP complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
U4/U6-U5 snRNP complex subunit SNU66
NP_014953.3
  • Component of the U4/U6.U5 snRNP complex; involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    894624..896387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183728.3 → NP_014953.3  TPA: U4/U6-U5 snRNP complex subunit SNU66 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014953.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W308, Q12420
    UniProtKB/TrEMBL
    B3LJX3, N1P3S4
    Conserved Domains (1) summary
    pfam03343
    Location:7 → 571
    SART-1; SART-1 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12420.1

Gene LinkOut

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