PMT3 dolichyl-phosphate-mannose-protein mannosyltransferase PMT3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PMT3
Official Full Name: dolichyl-phosphate-mannose-protein mannosyltransferase PMT3
Primary source: SGD:S000005848
Locus tag: YOR321W
See related: AllianceGenome:SGD:S000005848; FungiDB:YOR321W; VEuPathDB:YOR321W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable dolichyl-phosphate-mannose-protein mannosyltransferase activity. Involved in protein O-linked mannosylation. Located in endoplasmic reticulum. Part of dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt3p dimer complex and dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex. Human ortholog(s) of this gene implicated in lissencephaly and muscular dystrophy (multiple). Orthologous to human POMT2 (protein O-mannosyltransferase 2). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See PMT3 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (916030..918291)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables mannosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein O-linked glycosylation	IEA Inferred from Electronic Annotation more info
involved_in protein O-linked glycosylation	ISA Inferred from Sequence Alignment more info	PubMed
involved_in protein O-linked mannosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein O-linked mannosylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt3p dimer complex	IDA Inferred from Direct Assay more info	PubMed
part_of dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dolichyl-phosphate-mannose-protein mannosyltransferase PMT3

NP_014966.1

EC 2.4.1.109

Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

916030..918291

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183741.1 → NP_014966.1 TPA: dolichyl-phosphate-mannose-protein mannosyltransferase PMT3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014966.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W319, P47190

UniProtKB/TrEMBL

A6ZPF4, C7GNU2, C8ZH72, N1NYY4

Conserved Domains (1) summary

COG1928
Location:31 → 750

PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]