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ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein [ Homo sapiens (human) ]

Gene ID: 85450, updated on 5-Mar-2024

Summary

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Official Symbol
ITPRIPprovided by HGNC
Official Full Name
inositol 1,4,5-trisphosphate receptor interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:29370
See related
Ensembl:ENSG00000148841 MIM:620205; AllianceGenome:HGNC:29370
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
D1A; DANGER; KIAA1754; bA127L20; bA127L20.2
Summary
This gene encodes a membrane-associated protein that binds the inositol 1,4,5-trisphosphate receptor (ITPR). The encoded protein enhances the sensitivity of ITPR to intracellular calcium signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Expression
Broad expression in bone marrow (RPKM 60.0), esophagus (RPKM 14.1) and 17 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
10q25.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (104309700..104338465, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (105197853..105226599, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (106069458..106098223, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902497 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3981 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3983 Neighboring gene microRNA 4482 Neighboring gene glutathione S-transferase omega 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:106058991-106060190 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:106060509-106061008 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106075123-106075652 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106075653-106076181 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:106078667-106079168 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106083478-106084208 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106084209-106084937 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106086727-106087372 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106087373-106088018 Neighboring gene ITPRIP antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2798 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106089957-106090602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106090603-106091248 Neighboring gene Sharpr-MPRA regulatory region 8343 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3984 Neighboring gene Sharpr-MPRA regulatory region 11867 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2799 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:106109241-106110165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3987 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3989 Neighboring gene cilia and flagella associated protein 58 Neighboring gene CFAP58 divergent transcript Neighboring gene uncharacterized LOC124902590

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ITPRIP promotes glioma progression by linking MYL9 to DAPK1 inhibition. Cao C, et al. Cell Signal, 2021 Sep. PMID 34111521
  2. DANGER is involved in high glucose-induced radioresistance through inhibiting DAPK-mediated anoikis in non-small cell lung cancer. Kwon T, et al. Oncotarget, 2016 Feb 9. PMID 26769850, Free PMC Article
  3. PHYRN: a robust method for phylogenetic analysis of highly divergent sequences. Bhardwaj G, et al. PLoS One, 2012. PMID 22514627, Free PMC Article
  4. Ancient origin of the new developmental superfamily DANGER. Nikolaidis N, et al. PLoS One, 2007 Feb 14. PMID 17301879, Free PMC Article
  5. DANGER, a novel regulatory protein of inositol 1,4,5-trisphosphate-receptor activity. van Rossum DB, et al. J Biol Chem, 2006 Dec 1. PMID 16990268

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ITPRIP promotes glioma progression by linking MYL9 to DAPK1 inhibition.
    Title: ITPRIP promotes glioma progression by linking MYL9 to DAPK1 inhibition.
  2. The suggested model of how long noncoding RNAs (lncI) TPRIP-1 orchestrates signal transduction for IFN production illustrates the essential role of lncRNAs in virus elimination.
    Title: Long Noncoding RNA ITPRIP-1 Positively Regulates the Innate Immune Response through Promotion of Oligomerization and Activation of MDA5.
  3. High DANGER expression is involved in high glucose-induced radioresistance through inhibiting DAPK-mediated anoikis in non-small cell lung cancer.
    Title: DANGER is involved in high glucose-induced radioresistance through inhibiting DAPK-mediated anoikis in non-small cell lung cancer.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
  6. DANGER appears to allosterically modulate the sensitivity of IP(3) RtoCa(2+) inhibition, which likely alters IP(3)R-mediated Ca(2+) dynamics in cells where DANGER and IP(3)R are co-expressed
    Title: DANGER, a novel regulatory protein of inositol 1,4,5-trisphosphate-receptor activity.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with ITPRIP; predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1754

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
inositol 1,4,5-trisphosphate receptor-interacting protein
Names
DANGER family member 1A
inositol 1,4,5-triphosphate receptor-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001272012.2 → NP_001258941.1  inositol 1,4,5-trisphosphate receptor-interacting protein precursor

    See identical proteins and their annotated locations for NP_001258941.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AL162742
    Consensus CDS
    CCDS7557.1
    UniProtKB/Swiss-Prot
    D3DRA5, Q5JU17, Q8IWB1, Q96MS8, Q9C0A9
    Related
    ENSP00000350915.2, ENST00000358187.2
    Conserved Domains (3) summary
    pfam03281
    Location:351 → 479
    Mab-21; Mab-21 protein
    pfam06936
    Location:43 → 112
    Selenoprotein_S; Selenoprotein S (SelS)
    cl11433
    Location:12 → 73
    DivIC; Septum formation initiator

  2. NM_001272013.2 → NP_001258942.1  inositol 1,4,5-trisphosphate receptor-interacting protein precursor

    See identical proteins and their annotated locations for NP_001258942.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AL162742
    Consensus CDS
    CCDS7557.1
    UniProtKB/Swiss-Prot
    D3DRA5, Q5JU17, Q8IWB1, Q96MS8, Q9C0A9
    Related
    ENSP00000337178.1, ENST00000337478.3
    Conserved Domains (3) summary
    pfam03281
    Location:351 → 479
    Mab-21; Mab-21 protein
    pfam06936
    Location:43 → 112
    Selenoprotein_S; Selenoprotein S (SelS)
    cl11433
    Location:12 → 73
    DivIC; Septum formation initiator

  3. NM_033397.4 → NP_203755.1  inositol 1,4,5-trisphosphate receptor-interacting protein precursor

    See identical proteins and their annotated locations for NP_203755.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AL162742
    Consensus CDS
    CCDS7557.1
    UniProtKB/Swiss-Prot
    D3DRA5, Q5JU17, Q8IWB1, Q96MS8, Q9C0A9
    Related
    ENSP00000278071.2, ENST00000278071.6
    Conserved Domains (3) summary
    pfam03281
    Location:351 → 479
    Mab-21; Mab-21 protein
    pfam06936
    Location:43 → 112
    Selenoprotein_S; Selenoprotein S (SelS)
    cl11433
    Location:12 → 73
    DivIC; Septum formation initiator

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    104309700..104338465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270257.3 → XP_005270314.1  inositol 1,4,5-trisphosphate receptor-interacting protein isoform X1

    Conserved Domains (3) summary
    pfam03281
    Location:356 → 484
    Mab-21; Mab-21 protein
    pfam06936
    Location:48 → 117
    Selenoprotein_S; Selenoprotein S (SelS)
    cl11433
    Location:17 → 78
    DivIC; Septum formation initiator

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    105197853..105226599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367055.1 → XP_054223030.1  inositol 1,4,5-trisphosphate receptor-interacting protein isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IWB1.1 GenPept UniProtKB/Swiss-Prot:Q8IWB1

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