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KRE5 Kre5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854514, updated on 18-Sep-2024

Summary

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Official Symbol
KRE5
Official Full Name
Kre5p
Primary source
SGD:S000005863
Locus tag
YOR336W
See related
AllianceGenome:SGD:S000005863; FungiDB:YOR336W; VEuPathDB:YOR336W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables UDP-glucose:glycoprotein glucosyltransferase activity. Involved in fungal-type cell wall beta-glucan biosynthetic process. Located in endoplasmic reticulum. Orthologous to human UGGT1 (UDP-glucose glycoprotein glucosyltransferase 1) and UGGT2 (UDP-glucose glycoprotein glucosyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See KRE5 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (949773..953870)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Mrs2p Neighboring gene alanine--tRNA ligase Neighboring gene Tea1p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. KRE5 gene null mutant strains of Candida albicans are avirulent and have altered cell wall composition and hypha formation properties. Herrero AB, et al. Eukaryot Cell, 2004 Dec. PMID 15590817, Free PMC Article
  2. The yeast KRE5 gene encodes a probable endoplasmic reticulum protein required for (1----6)-beta-D-glucan synthesis and normal cell growth. Meaden P, et al. Mol Cell Biol, 1990 Jun. PMID 2188106, Free PMC Article
  3. Loss of function of KRE5 suppresses temperature sensitivity of mutants lacking mitochondrial anionic lipids. Zhong Q, et al. Mol Biol Cell, 2005 Feb. PMID 15563612, Free PMC Article
  4. Functional, comparative and cell biological analysis of Saccharomyces cerevisiae Kre5p. Levinson JN, et al. Yeast, 2002 Oct. PMID 12271460
  5. Saccharomyces cerevisiae Big1p, a putative endoplasmic reticulum membrane protein required for normal levels of cell wall beta-1,6-glucan. Azuma M, et al. Yeast, 2002 Jun 30. PMID 12112232

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables UDP-glucose:glycoprotein glucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-glucose:glycoprotein glucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-glucose:glycoprotein glucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in UDP-glucosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in fungal-type cell wall beta-glucan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein N-linked glycosylation via asparagine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum TAS
Traceable Author Statement
more info
 PubMed 
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Kre5p
NP_014981.1
  • Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    949773..953870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183756.1 → NP_014981.1  TPA: Kre5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014981.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W331, P22023, Q12190
    UniProtKB/TrEMBL
    A6ZPG6, B3LJZ5, N1P3U6
    Conserved Domains (3) summary
    pfam18401
    Location:254 → 372
    Thioredoxin_13; Thioredoxin-like domain
    pfam18402
    Location:419 → 576
    Thioredoxin_14; Thioredoxin-like domain
    pfam18404
    Location:1095 → 1306
    Glyco_transf_24; Glucosyltransferase 24
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P22023.2

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