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UBC11 putative E2 ubiquitin-protein ligase UBC11 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854517, updated on 18-Sep-2024

Summary

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Official Symbol
UBC11
Official Full Name
putative E2 ubiquitin-protein ligase UBC11
Primary source
SGD:S000005866
Locus tag
YOR339C
See related
AllianceGenome:SGD:S000005866; FungiDB:YOR339C; VEuPathDB:YOR339C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process; protein polyubiquitination; and regulation of mitotic metaphase/anaphase transition. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human UBE2C (ubiquitin conjugating enzyme E2 C). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See UBC11 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (958362..958832, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Tea1p Neighboring gene uncharacterized protein Neighboring gene DNA-directed RNA polymerase I subunit RPA43 Neighboring gene DNA-directed RNA polymerase I core subunit RPA190

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional analysis of the Saccharomyces cerevisiae UBC11 gene. Townsley FM, et al. Yeast, 1998 Jun 15. PMID 9675819
  2. Proteasome Activity Is Influenced by the HECT_2 Protein Ipa1 in Budding Yeast. Lutz AP, et al. Genetics, 2018 May. PMID 29519818, Free PMC Article
  3. Ubiquitin-dependent protein degradation. Hochstrasser M. Annu Rev Genet, 1996. PMID 8982460
  4. Tmc1 Is a Dynamically Regulated Effector of the Rpn4 Proteotoxic Stress Response. Guerra-Moreno A, et al. J Biol Chem, 2016 Jul 8. PMID 27226598, Free PMC Article
  5. Identification of human intracellular targets of the medicinal Herb St. John's Wort by chemical-genetic profiling in yeast. McCue PP, et al. J Agric Food Chem, 2008 Nov 26. PMID 18975972, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein monoubiquitination TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitotic metaphase/anaphase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IC
Inferred by Curator
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative E2 ubiquitin-protein ligase UBC11
NP_014984.3
  • Ubiquitin-conjugating enzyme; most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    958362..958832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183759.3 → NP_014984.3  TPA: putative E2 ubiquitin-protein ligase UBC11 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014984.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W334, P52492
    UniProtKB/TrEMBL
    A6ZPG9, B3LJZ8, C7GNS7, C8ZH91, G2WNK1, N1NX16
    Conserved Domains (1) summary
    COG5078
    Location:11 → 156
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52492.1

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