U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PUT4 proline permease PUT4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854530, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
PUT4
Official Full Name
proline permease PUT4
Primary source
SGD:S000005875
Locus tag
YOR348C
See related
AllianceGenome:SGD:S000005875; FungiDB:YOR348C; VEuPathDB:YOR348C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables L-proline transmembrane transporter activity. Involved in gamma-aminobutyric acid transport and proline transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa 68. Orthologous to several human genes including SLC7A1 (solute carrier family 7 member 1); SLC7A14 (solute carrier family 7 member 14); and SLC7A2 (solute carrier family 7 member 2). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PUT4 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (986899..988782, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene deoxycytidyl transferase Neighboring gene pyruvate kinase PYK2 Neighboring gene Cin1p Neighboring gene Mne1p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases. Vandenbol M, et al. Gene, 1989 Nov 15. PMID 2687114
  2. Proline transport and stress tolerance of ammonia-insensitive mutants of the PUT4-encoded proline-specific permease in yeast. Poole K, et al. J Gen Appl Microbiol, 2009 Dec. PMID 20118607
  3. Ammonia regulation of amino acid permeases in Saccharomyces cerevisiae. Courchesne WE, et al. Mol Cell Biol, 1983 Apr. PMID 6343842, Free PMC Article
  4. Nitrogen catabolite regulation of proline permease in Saccharomyces cerevisiae. Cloning of the PUT4 gene and study of PUT4 RNA levels in wild-type and mutant strains. Jauniaux JC, et al. Eur J Biochem, 1987 May 4. PMID 3552672
  5. Engineering of yeast Put4 permease and its application to lager yeast for efficient proline assimilation. Omura F, et al. Biosci Biotechnol Biochem, 2005 Jun. PMID 15973048

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables L-proline transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables L-proline transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neutral L-amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in gamma-aminobutyric acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in gamma-aminobutyric acid transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neutral amino acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proline transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proline transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
proline permease PUT4
NP_014993.1
  • Proline permease; required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    986899..988782 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183768.1 → NP_014993.1  TPA: proline permease PUT4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014993.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W343, P15380
    UniProtKB/TrEMBL
    A6ZPH8, B3LK05, B5VSM4, C7GNS0, G2WNK8, N1NXI3
    Conserved Domains (1) summary
    TIGR00913
    Location:107 → 593
    2A0310; amino acid permease (yeast)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15380.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools