FRE5 putative ferric-chelate reductase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: FRE5
Gene description: putative ferric-chelate reductase
Primary source: FungiDB:YOR384W
Locus tag: YOR384W
See related: SGD:S000005911; AllianceGenome:SGD:S000005911; VEuPathDB:YOR384W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable ferric-chelate reductase activity. Predicted to be involved in cellular iron ion homeostasis; copper ion import; and iron ion transport. Located in mitochondrion. Human ortholog(s) of this gene implicated in X-linked chronic granulomatous disease; chronic granulomatous disease; congenital hypothyroidism; immunodeficiency 34; and thyroid dyshormonogenesis 6. Orthologous to several human genes including NOX1 (NADPH oxidase 1); NOX3 (NADPH oxidase 3); and NOX4 (NADPH oxidase 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See FRE5 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (1061564..1063648)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ferric-chelate reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables ferric-chelate reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ferric-chelate reductase activity	IEA Inferred from Electronic Annotation more info
enables ferric-chelate reductase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in copper ion import	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular iron ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative ferric-chelate reductase

NP_015029.1

EC 1.16.1.9

Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

1061564..1063648

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183804.1 → NP_015029.1 TPA: putative ferric-chelate reductase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015029.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W377, Q08908

UniProtKB/TrEMBL

A0A8H4BXG9, A6ZPL2, B3LK38, B5VSQ5, C7GVG2, C8ZHD2, N1NXK5

Conserved Domains (3) summary

cd06186
Location:429 → 601

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam08030
Location:531 → 674

NAD_binding_6; Ferric reductase NAD binding domain

pfam01794
Location:277 → 388

Ferric_reduct; Ferric reductase like transmembrane component