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BI4 intron-encoded RNA maturase bI4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854582, updated on 18-Sep-2024

Summary

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Official Symbol
BI4
Official Full Name
intron-encoded RNA maturase bI4
Primary source
SGD:S000007273
Locus tag
Q0120
See related
AllianceGenome:SGD:S000007273; FungiDB:Q0120; VEuPathDB:Q0120
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Saccharomyces cerevisiae S288C (strain: S288C, substrain: FY1679)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA binding activity. Involved in Group I intron splicing and mitochondrial mRNA processing. Located in mitochondrion. Human ortholog(s) of this gene implicated in ovarian carcinoma and urinary bladder cancer. Orthologous to human MT-CYB (mitochondrially encoded cytochrome b). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See BI4 in Genome Data Viewer
Sequence:
Chromosome: MT; NC_001224.1 (36540..42251)

Chromosome MT - NC_001224.1Genomic Context describing neighboring genes Neighboring gene F1F0 ATP synthase subunit a Neighboring gene tRNA-Glu Neighboring gene cytochrome b mRNA maturase bI2 Neighboring gene cytochrome b mRNA maturase bI3 Neighboring gene cytochrome b Neighboring gene tRNA-Ser Neighboring gene F0 ATP synthase subunit c

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001224.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Synthesis and function of the mitochondrial intron--encoded bI4 RNA maturase from Saccharomyces cerevisiae. Effects of upstream frame-shift mutations. Goguel V, et al. Curr Genet, 1989 Oct. PMID 2560681
  2. A mitochondrial RNA maturase gene transferred to the yeast nucleus can control mitochondrial mRNA splicing. Banroques J, et al. Cell, 1986 Sep 12. PMID 2875797
  3. Efficient splicing of two yeast mitochondrial introns controlled by a nuclear-encoded maturase. Banroques J, et al. EMBO J, 1987 Apr. PMID 3036491, Free PMC Article
  4. Connections between RNA splicing and DNA intron mobility in yeast mitochondria: RNA maturase and DNA endonuclease switching experiments. Goguel V, et al. Mol Cell Biol, 1992 Feb. PMID 1310149, Free PMC Article
  5. Novel hybrid maturases in unstable pseudorevertants of maturaseless mutants of yeast mitochondrial DNA. Anziano PQ, et al. Nucleic Acids Res, 1990 Jun 11. PMID 1972561, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to ubiquinol-cytochrome-c reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Group I intron splicing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Group I intron splicing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial mRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
intron-encoded RNA maturase bI4
NP_009316.1
  • Mitochondrial mRNA maturase; forms a complex with Nam2p to mediate splicing of the bI4 intron of the COB gene; encoded by both exon and intron sequences of partially processed COB mRNA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001224.1 Reference assembly

    Range
    36540..42251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_009316.1 intron-encoded RNA maturase bI4 (mitochondrion) [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009316.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A0A0A7NYH9, P03879, Q02324, Q9ZZW6
    UniProtKB/TrEMBL
    G2HKE5
    Conserved Domains (4) summary
    COG1372
    Location:363 → 592
    Hop; Intein/homing endonuclease [Replication, recombination and repair, Mobilome: prophages, transposons]
    cd00284
    Location:8 → 207
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
    pfam00961
    Location:408 → 495
    LAGLIDADG_1; LAGLIDADG endonuclease
    cl00193
    Location:208 → 255
    cytochrome_b_C; Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P03879.2

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