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VAR1 mitochondrial 37S ribosomal protein VAR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854586, updated on 18-Sep-2024

Summary

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Official Symbol
VAR1
Official Full Name
mitochondrial 37S ribosomal protein VAR1
Primary source
SGD:S000007275
Locus tag
Q0140
See related
AllianceGenome:SGD:S000007275; FungiDB:Q0140; VEuPathDB:Q0140
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Saccharomyces cerevisiae S288C (strain: S288C, substrain: FY1679)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
uS3m
Summary
A structural constituent of ribosome. Involved in mitochondrial translation. Located in mitochondrial ribosome. Part of mitochondrial small ribosomal subunit. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See VAR1 in Genome Data Viewer
Sequence:
Chromosome: MT; NC_001224.1 (48901..50097)

Chromosome MT - NC_001224.1Genomic Context describing neighboring genes Neighboring gene F0 ATP synthase subunit c Neighboring gene tRNA-Ser Neighboring gene 21S ribosomal RNA Neighboring gene intron-encoded endonuclease I-SceI Neighboring gene tRNA-Thr

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001224.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biogenesis of mitochondria: a temperature sensitivity mutation affecting the mitochondrially synthesized var1 protein of Saccharomyces cerevisiae. Murphy M, et al. Arch Biochem Biophys, 1980 Aug. PMID 6250484
  2. Respiration deficient mutants in the A+T-rich region on yeast mitochondrial DNA containing the var1 gene. Zassenhaus HP, et al. Curr Genet, 1982 Dec. PMID 24186543
  3. Mitochondrially-encoded protein Var1 promotes loss of respiratory function in Saccharomyces cerevisiae under stressful conditions. Litvinchuk AV, et al. Eur J Cell Biol, 2013 Apr-May. PMID 23523087
  4. The chaperonin-related protein Tcm62p ensures mitochondrial gene expression under heat stress. Klanner C, et al. FEBS Lett, 2000 Mar 31. PMID 10745098
  5. Identification of a cAMP-dependent protein-DNA interaction at a sequence near the yeast mitochondrial rRNA genes. Rahman MU, et al. Biochem Mol Biol Int, 1996 Aug. PMID 8876964

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The translational activator Sov1 coordinates mitochondrial gene expression with mitoribosome biogenesis.
    Title: The translational activator Sov1 coordinates mitochondrial gene expression with mitoribosome biogenesis.
  2. Var1 physically interacts with mitochondrial DNA and under stress negatively regulates its maintenance.
    Title: Mitochondrially-encoded protein Var1 promotes loss of respiratory function in Saccharomyces cerevisiae under stressful conditions.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mitochondrial 37S ribosomal protein VAR1
NP_009320.1
  • Mitochondrial ribosomal protein of the small subunit; mitochondrially-encoded; polymorphic in different strains due to variation in number of AAT (asparagine) codons; translated near the mitochondrial inner membrane; may have a role in loss of mitochondrial DNA under stress conditions

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001224.1 Reference assembly

    Range
    48901..50097
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_009320.1 mitochondrial 37S ribosomal protein VAR1 (mitochondrion) [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009320.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A0A0A7NYM3, A2KBL8, P02381, Q95946, Q9ZZW5
    UniProtKB/TrEMBL
    A0A2L1IPY2
    Conserved Domains (1) summary
    pfam05316
    Location:55 → 398
    VAR1; Mitochondrial ribosomal protein (VAR1)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02381.3

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