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AI1 intron-encoded reverse transcriptase aI1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854593, updated on 2-Nov-2024

Summary

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Official Symbol
AI1
Official Full Name
intron-encoded reverse transcriptase aI1
Primary source
SGD:S000007261
Locus tag
Q0050
See related
AllianceGenome:SGD:S000007261; FungiDB:Q0050; VEuPathDB:Q0050
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Saccharomyces cerevisiae S288C (strain: S288C, substrain: FY1679)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA-directed DNA polymerase activity. Involved in RNA-templated DNA biosynthetic process; homing of group II introns; and mRNA processing. Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See AI1 in Genome Data Viewer
Sequence:
Chromosome: MT; NC_001224.1 (13818..16322)

Chromosome MT - NC_001224.1Genomic Context describing neighboring genes Neighboring gene 15S ribosomal RNA Neighboring gene tRNA-Trp Neighboring gene intron-encoded DNA endonuclease aI5 alpha Neighboring gene cytochrome c oxidase subunit 1 Neighboring gene intron-encoded reverse transcriptase aI2 Neighboring gene intron-encoded DNA endonuclease aI3 Neighboring gene intron-encoded DNA endonuclease aI4 Neighboring gene intron-encoded DNA endonuclease aI5 beta Neighboring gene F1F0 ATP synthase subunit 8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001224.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNA splicing in yeast mitochondria: DNA sequence analysis of mit- mutants deficient in the excision of introns aI1 and aI2 of the gene for subunit I of cytochrome c oxidase. van der Veen R, et al. Curr Genet, 1988 Mar. PMID 2838183
  2. Nuclear omnipotent suppressors of premature termination codons in mitochondrial genes affect the 37S mitoribosomal subunit. Boguta M, et al. Curr Genet, 1988 Feb. PMID 3286020
  3. Retrotransposition of a yeast group II intron occurs by reverse splicing directly into ectopic DNA sites. Dickson L, et al. Proc Natl Acad Sci U S A, 2001 Nov 6. PMID 11687644, Free PMC Article
  4. Pentamidine inhibits mitochondrial intron splicing and translation in Saccharomyces cerevisiae. Zhang Y, et al. RNA, 2000 Jul. PMID 10917591, Free PMC Article
  5. Transposition of group II intron aI1 in yeast and invasion of mitochondrial genes at new locations. Mueller MW, et al. Nature, 1993 Nov 11. PMID 8232557

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA-directed DNA polymerase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA-templated DNA biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homing of group II introns IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homing of group II introns IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial mRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
intron-encoded reverse transcriptase aI1
NP_009310.1
  • Reverse transcriptase required for splicing of the COX1 pre-mRNA; encoded by a mobile group II intron within the mitochondrial COX1 gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001224.1 Reference assembly

    Range
    13818..16322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_009310.1 intron-encoded reverse transcriptase aI1 (mitochondrion) [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009310.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A0A0A7NYG1, P03875, Q9ZZX5
    UniProtKB/TrEMBL
    G2HKD9
    Conserved Domains (5) summary
    cd00085
    Location:771 → 823
    HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
    cd01651
    Location:311 → 577
    RT_G2_intron; RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable ...
    TIGR04416
    Location:260 → 675
    group_II_RT_mat; group II intron reverse transcriptase/maturase
    pfam01348
    Location:602 → 759
    Intron_maturas2; Type II intron maturase
    cl00275
    Location:3 → 56
    Heme_Cu_Oxidase_I; Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P03875.2

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