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AI3 intron-encoded DNA endonuclease aI3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854595, updated on 2-Nov-2024

Summary

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Official Symbol
AI3
Official Full Name
intron-encoded DNA endonuclease aI3
Primary source
SGD:S000007263
Locus tag
Q0060
See related
AllianceGenome:SGD:S000007263; FungiDB:Q0060; VEuPathDB:Q0060
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Saccharomyces cerevisiae S288C (strain: S288C, substrain: FY1679)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables endonuclease activity. Predicted to be involved in aerobic respiration and respiratory electron transport chain. Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex IV. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See AI3 in Genome Data Viewer
Sequence:
Chromosome: MT; NC_001224.1 (13818..19996)

Chromosome MT - NC_001224.1Genomic Context describing neighboring genes Neighboring gene 15S ribosomal RNA Neighboring gene tRNA-Trp Neighboring gene intron-encoded DNA endonuclease aI5 alpha Neighboring gene cytochrome c oxidase subunit 1 Neighboring gene intron-encoded reverse transcriptase aI1 Neighboring gene intron-encoded reverse transcriptase aI2 Neighboring gene intron-encoded DNA endonuclease aI4 Neighboring gene intron-encoded DNA endonuclease aI5 beta Neighboring gene F1F0 ATP synthase subunit 8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001224.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. I-Sce III an intron-encoded DNA endonuclease from yeast mitochondria. Asymmetrical DNA binding properties and cleavage reaction. Schapira M, et al. Nucleic Acids Res, 1993 Aug 11. PMID 8367285, Free PMC Article
  2. Two homologous introns from related Saccharomyces species differ in their mobility. Szczepanek T, et al. Gene, 1994 Feb 11. PMID 8112577
  3. The mobile group I intron 3 alpha of the yeast mitochondrial COXI gene encodes a 35-kDa processed protein that is an endonuclease but not a maturase. Guo WW, et al. J Biol Chem, 1995 Jun 30. PMID 7797552
  4. Splice site selection by intron aI3 of the COX1 gene from Saccharomyces cerevisiae. Winter AJ, et al. Nucleic Acids Res, 1992 Aug 11. PMID 1324471, Free PMC Article
  5. Indication for deletion of two introns in the oxi-3 gene of a respiratory-competent Saccharomyces cerevisiae strain. Mink M. Biochem Genet, 1988 Aug. PMID 3067726

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to cytochrome-c oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytochrome-c oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in aerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aerobic respiration IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in intron homing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in respiratory electron transport chain IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion TAS
Traceable Author Statement
more info
 PubMed 
part_of respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
intron-encoded DNA endonuclease aI3
NP_009308.2
  • Endonuclease I-SceIII; encoded by a mobile group I intron within the mitochondrial COX1 gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001224.1 Reference assembly

    Range
    13818..19996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_009308.2 intron-encoded DNA endonuclease aI3 (mitochondrion) [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009308.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A0A0A7P044, P03877, Q35790, Q9ZZX3
    UniProtKB/TrEMBL
    A0A0H3WJP7
    Conserved Domains (2) summary
    pfam00961
    Location:113 → 209
    LAGLIDADG_1; LAGLIDADG endonuclease
    cl00275
    Location:9 → 81
    Heme_Cu_Oxidase_I; Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P03877.3

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