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AI5_ALPHA intron-encoded DNA endonuclease aI5 alpha [ Saccharomyces cerevisiae S288C ]

Gene ID: 854597, updated on 14-Nov-2024

Summary

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Official Symbol
AI5_ALPHA
Official Full Name
intron-encoded DNA endonuclease aI5 alpha
Primary source
SGD:S000007265
Locus tag
Q0070
See related
AllianceGenome:SGD:S000007265; FungiDB:Q0070; VEuPathDB:Q0070
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Saccharomyces cerevisiae S288C (strain: S288C, substrain: FY1679)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables endonuclease activity. Involved in movement of group I intron. Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex IV. Orthologous to human MT-CO1 (mitochondrially encoded cytochrome c oxidase I). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See AI5_ALPHA in Genome Data Viewer
Sequence:
Chromosome: MT; NC_001224.1 (13818..23167)

Chromosome MT - NC_001224.1Genomic Context describing neighboring genes Neighboring gene 15S ribosomal RNA Neighboring gene tRNA-Trp Neighboring gene cytochrome c oxidase subunit 1 Neighboring gene intron-encoded reverse transcriptase aI1 Neighboring gene intron-encoded reverse transcriptase aI2 Neighboring gene intron-encoded DNA endonuclease aI3 Neighboring gene intron-encoded DNA endonuclease aI4 Neighboring gene intron-encoded DNA endonuclease aI5 beta Neighboring gene F1F0 ATP synthase subunit 8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001224.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A map of the binding site for catalytic domain 5 in the core of a group II intron ribozyme. Konforti BB, et al. EMBO J, 1998 Dec 1. PMID 9843514, Free PMC Article
  2. Structure and activity of the mitochondrial intron-encoded endonuclease, I-SceIV. Wernette CM. Biochem Biophys Res Commun, 1998 Jul 9. PMID 9675098
  3. The yeast mitochondrial intron aI5 alpha: associated endonuclease activity and in vivo mobility. Séraphin B, et al. Gene, 1992 Apr 1. PMID 1314207
  4. The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae. Foury F, et al. FEBS Lett, 1998 Dec 4. PMID 9872396
  5. A complex of Cox4 and mitochondrial Hsp70 plays an important role in the assembly of the cytochrome c oxidase. Böttinger L, et al. Mol Biol Cell, 2013 Sep. PMID 23864706, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to cytochrome-c oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytochrome-c oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables endonuclease activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in aerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aerobic respiration IEA
Inferred from Electronic Annotation
more info
  
involved_in intron homing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in movement of group I intron IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in respiratory electron transport chain IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion TAS
Traceable Author Statement
more info
 PubMed 
part_of respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
intron-encoded DNA endonuclease aI5 alpha
NP_009306.1
  • Endonuclease I-SceIV; involved in intron mobility; encoded by a mobile group I intron within the mitochondrial COX1 gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001224.1 Reference assembly

    Range
    13818..23167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_009306.1 intron-encoded DNA endonuclease aI5 alpha (mitochondrion) [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009306.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A0A0A7NYD1, Q8W770, Q9ZZX1
    UniProtKB/TrEMBL
    G2HKD6
    Conserved Domains (3) summary
    pfam00115
    Location:13 → 325
    COX1; Cytochrome C and Quinol oxidase polypeptide I
    pfam03161
    Location:424 → 601
    LAGLIDADG_2; LAGLIDADG DNA endonuclease family
    cl00275
    Location:9 → 324
    Heme_Cu_Oxidase_I; Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ZZX1.1

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