POT1 acetyl-CoA C-acyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: POT1
Official Full Name: acetyl-CoA C-acyltransferase
Primary source: SGD:S000001422
Locus tag: YIL160C
See related: AllianceGenome:SGD:S000001422; FungiDB:YIL160C; VEuPathDB:YIL160C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: FOX3; POX3
Summary: Enables acetyl-CoA C-acyltransferase activity and mRNA binding activity. Involved in fatty acid beta-oxidation. Located in mitochondrial intermembrane space and peroxisomal matrix. Orthologous to human ACAA1 (acetyl-CoA acyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See POT1 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (40191..41444, complement)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that only ScFox3-GFP, with an intact PTS2 peroxisome signal sequence, is able to translocate into peroxisomes, and suggest that ScFox3 is a natural antifungal agent found.
Title: Antifungal activity of Saccharomyces cerevisiae peroxisomal 3-ketoacyl-CoA thiolase.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables acetyl-CoA C-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetyl-CoA C-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetyl-CoA C-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phenylacetate catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in peroxisomal matrix	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal matrix	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: acetyl-CoA C-acyltransferase

NP_012106.1

EC 2.3.1.16

3-ketoacyl-CoA thiolase with broad chain length specificity; cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

40191..41444 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179508.1 → NP_012106.1 TPA: acetyl-CoA C-acyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012106.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVC6, P27796

UniProtKB/TrEMBL

A6ZVB6, B3LU08, B5VKF2, C7GUS6, C8ZAV2, G2WFZ1, N1P1Z7

Conserved Domains (1) summary

cd00751
Location:37 → 414

thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...