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COA1 Coa1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854649, updated on 2-Nov-2024

Summary

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Official Symbol
COA1
Official Full Name
Coa1p
Primary source
SGD:S000001419
Locus tag
YIL157C
See related
AllianceGenome:SGD:S000001419; FungiDB:YIL157C; VEuPathDB:YIL157C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See COA1 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (46949..47542, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene formin BNR1 Neighboring gene Aim20p Neighboring gene mitofissin Neighboring gene ubiquitin-specific protease UBP7

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mimicking a SURF1 allele reveals uncoupling of cytochrome c oxidase assembly from translational regulation in yeast. Reinhold R, et al. Hum Mol Genet, 2011 Jun 15. PMID 21470975
  2. Stabilization of Cox1p intermediates by the Cox14p-Coa3p complex. McStay GP, et al. FEBS Lett, 2013 Apr 2. PMID 23434581, Free PMC Article
  3. Modular assembly of yeast cytochrome oxidase. McStay GP, et al. Mol Biol Cell, 2013 Feb. PMID 23266989, Free PMC Article
  4. Coa2 is an assembly factor for yeast cytochrome c oxidase biogenesis that facilitates the maturation of Cox1. Pierrel F, et al. Mol Cell Biol, 2008 Aug. PMID 18541668, Free PMC Article
  5. The role of Coa2 in hemylation of yeast Cox1 revealed by its genetic interaction with Cox10. Bestwick M, et al. Mol Cell Biol, 2010 Jan. PMID 19841065, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in cytochrome c oxidase assemb
    Title: Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in cytochrome c oxidase assembly.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrial cytochrome c oxidase assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial cytochrome c oxidase assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial cytochrome c oxidase assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial cytochrome c oxidase assembly IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Coa1p
NP_012109.1
  • Mitochondrial inner membrane protein; required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    46949..47542 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179505.1 → NP_012109.1  TPA: Coa1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012109.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVC9, P40452
    UniProtKB/TrEMBL
    A6ZVB9, B3LU05, C7GUS3, C8ZAV5, G2WFZ4, N1P944
    Conserved Domains (1) summary
    pfam08695
    Location:74 → 189
    Coa1; Cytochrome oxidase complex assembly protein 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40452.1

Gene LinkOut

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