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AXL2 Axl2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854666, updated on 2-Nov-2024

Summary

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Official Symbol
AXL2
Official Full Name
Axl2p
Primary source
SGD:S000001402
Locus tag
YIL140W
See related
AllianceGenome:SGD:S000001402; FungiDB:YIL140W; VEuPathDB:YIL140W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
BUD10; SRO4
Summary
Predicted to enable calcium ion binding activity. Involved in axial cellular bud site selection. Located in cellular bud neck septin ring; incipient cellular bud site; and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See AXL2 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (85366..87837)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene TFIIH/NER complex ATPase/helicase subunit SSL2 Neighboring gene chaperonin-containing T-complex subunit CCT2 Neighboring gene Rev7p Neighboring gene tropomyosin TPM2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cadherin-like domains in alpha-dystroglycan, alpha/epsilon-sarcoglycan and yeast and bacterial proteins. Dickens NJ, et al. Curr Biol, 2002 Mar 19. PMID 11909544
  2. Bud10p directs axial cell polarization in budding yeast and resembles a transmembrane receptor. Halme A, et al. Curr Biol, 1996 May 1. PMID 8805277
  3. Contact of cis-Golgi with ER exit sites executes cargo capture and delivery from the ER. Kurokawa K, et al. Nat Commun, 2014 Apr 14. PMID 24728174, Free PMC Article
  4. Promoter-dependent nuclear RNA degradation ensures cell cycle-specific gene expression. Catala M, et al. Commun Biol, 2019. PMID 31240249, Free PMC Article
  5. Cell cycle programs of gene expression control morphogenetic protein localization. Lord M, et al. J Cell Biol, 2000 Dec 25. PMID 11134078, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that Axl2p plays sequential and distinct roles in the regulation of cellular morphogenesis in yeast cell cycle.
    Title: Sequential and distinct roles of the cadherin domain-containing protein Axl2p in cell polarization in yeast cell cycle.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in axial cellular bud site selection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck septin ring IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in incipient cellular bud site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Axl2p
NP_012126.1
  • Integral plasma membrane protein; required for axial budding in haploid cells; localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    85366..87837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179488.1 → NP_012126.1  TPA: Axl2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012126.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVE6, P38928, Q96VY8
    UniProtKB/TrEMBL
    A6ZVD5, C8ZAX3
    Conserved Domains (3) summary
    cd11303
    Location:28 → 115
    Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
    smart00736
    Location:352 → 447
    CADG; Dystroglycan-type cadherin-like domains
    pfam08693
    Location:496 → 533
    SKG6; Transmembrane alpha-helix domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38928.1

Gene LinkOut

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