POG1 Pog1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: POG1
Official Full Name: Pog1p
Primary source: SGD:S000001384
Locus tag: YIL122W
See related: AllianceGenome:SGD:S000001384; FungiDB:YIL122W; VEuPathDB:YIL122W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II; re-entry into mitotic cell cycle after pheromone arrest; and sporulation resulting in formation of a cellular spore. Located in chromatin. [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

These results suggest that Pog1 controls the cell cycle and its phosphorylated form is downregulated by Dma2.
Title: The transcriptional activator Pog1 controls cell cycle, and its phosphorylated form is downregulated by the ubiquitin ligase Dma2 in Saccharomyces cerevisiae.
These results suggest that the overexpression of Kin28 and Pog1 enhances the protein refolding and degradation pathways in rsp5(A401E) cells.
Title: Overexpression of two transcriptional factors, Kin28 and Pog1, suppresses the stress sensitivity caused by the rsp5 mutation in Saccharomyces cerevisiae.
Induction of the CLB5 promoter requires MCB sequences.
Title: Meiosis-specific regulation of the Saccharomyces cerevisiae S-phase cyclin CLB5 is dependent on MluI cell cycle box (MCB) elements in its promoter but is independent of MCB-binding factor activity.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in re-entry into mitotic cell cycle after pheromone arrest	IGI Inferred from Genetic Interaction more info	PubMed
involved_in re-entry into mitotic cell cycle after pheromone arrest	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sporulation resulting in formation of a cellular spore	IDA Inferred from Direct Assay more info	PubMed
involved_in sporulation resulting in formation of a cellular spore	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_012144.1

DNA-binding transcriptional activator; involved in cell cycle regulation; overexpression promotes recovery from pheromone induced arrest via CLN1/2 transcription, induction of of IME1 during sporulation, and suppression of stress sensitivity resulting from mutation of the E3 ubiquitin ligase Rsp5p; binds upstream of BAR1 and cell cycle-related genes; phosphorylated form may be ubiquitinated by Dma2p; potential Cdc28p substrate; regulated by Swi4/6 cell-cycle box binding factor (SBF)