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FMC1 Fmc1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854709, updated on 9-Jun-2024

Summary

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Gene symbol
FMC1
Gene description
Fmc1p
Primary source
FungiDB:YIL098C
Locus tag
YIL098C
See related
SGD:S000001360; AllianceGenome:SGD:S000001360; VEuPathDB:YIL098C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in macroautophagy and mitochondrial proton-transporting ATP synthase complex assembly. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See FMC1 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (179772..180239, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Xbp1p Neighboring gene glucan 1,4-alpha-glucosidase Neighboring gene glucose-induced degradation complex subunit FYV10 Neighboring gene 25S rRNA (uracil2634-N3)-methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Newly imported proteins in mitochondria are particularly sensitive to aggregation. Vazquez-Calvo C, et al. Acta Physiol (Oxf), 2023 Jul. PMID 37171464, Free PMC Article
  2. A yeast-based assay identifies drugs active against human mitochondrial disorders. Couplan E, et al. Proc Natl Acad Sci U S A, 2011 Jul 19. PMID 21715656, Free PMC Article
  3. Defining the pathogenesis of the human Atp12p W94R mutation using a Saccharomyces cerevisiae yeast model. Meulemans A, et al. J Biol Chem, 2010 Feb 5. PMID 19933271, Free PMC Article
  4. Increasing mitochondrial substrate-level phosphorylation can rescue respiratory growth of an ATP synthase-deficient yeast. Schwimmer C, et al. J Biol Chem, 2005 Sep 2. PMID 15975925
  5. Impairing the bioenergetic status and the biogenesis of mitochondria triggers mitophagy in yeast. Priault M, et al. Cell Death Differ, 2005 Dec. PMID 15947785

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that the suppression of the respiratory-growth-deficient fmc1 by the overexpressed Odc1p was not due to a restored stable ATP synthase.
    Title: Increasing mitochondrial substrate-level phosphorylation can rescue respiratory growth of an ATP synthase-deficient yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial proton-transporting ATP synthase complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial proton-transporting ATP synthase complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial proton-transporting ATP synthase complex assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitochondrial proton-transporting ATP synthase complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Fmc1p
NP_012168.3
  • Mitochondrial matrix protein; required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    179772..180239 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179446.3 → NP_012168.3  TPA: Fmc1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012168.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVI9, P40491
    UniProtKB/TrEMBL
    A0A8H4BZA3, A6ZVH9, B3LTU5, C7GKM5, C8ZAF2, G2WG54, N1P2H5
    Conserved Domains (1) summary
    pfam13233
    Location:108 → 152
    Complex1_LYR_2; Complex1_LYR-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40491.1

Gene LinkOut

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