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SDS3 Sds3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854725, updated on 1-Aug-2024

Summary

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Gene symbol
SDS3
Gene description
Sds3p
Primary source
FungiDB:YIL084C
Locus tag
YIL084C
See related
SGD:S000001346; AllianceGenome:SGD:S000001346; VEuPathDB:YIL084C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to histone deacetylase activity. Involved in several processes, including cell adhesion involved in single-species biofilm formation; regulation of gene expression; and regulation of invasive growth in response to glucose limitation. Located in cytosol and nucleus. Part of Rpd3L complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SDS3 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (202276..203259, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene putative mannosyltransferase Neighboring gene phosphopantothenate--cysteine ligase CAB2 Neighboring gene gag-pol fusion protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sds3 (suppressor of defective silencing 3) is an integral component of the yeast Sin3[middle dot]Rpd3 histone deacetylase complex and is required for histone deacetylase activity. Lechner T, et al. J Biol Chem, 2000 Dec 29. PMID 11024051
  2. Chromatin Regulation by the NuA4 Acetyltransferase Complex Is Mediated by Essential Interactions Between Enhancer of Polycomb (Epl1) and Esa1. Searle NE, et al. Genetics, 2017 Mar. PMID 28108589, Free PMC Article
  3. Evidence that the transcriptional regulators SIN3 and RPD3, and a novel gene (SDS3) with similar functions, are involved in transcriptional silencing in S. cerevisiae. Vannier D, et al. Genetics, 1996 Dec. PMID 8978024, Free PMC Article
  4. NuA4 acetyltransferase is required for efficient nucleotide excision repair in yeast. Hodges AJ, et al. DNA Repair (Amst), 2019 Jan. PMID 30473425, Free PMC Article
  5. The roles of the catalytic and noncatalytic activities of Rpd3L and Rpd3S in the regulation of gene transcription in yeast. Yeheskely-Hayon D, et al. PLoS One, 2013. PMID 24358376, Free PMC Article

See all (112) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to histone deacetylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell adhesion involved in single-species biofilm formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of rDNA heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of silent mating-type cassette heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of invasive growth in response to glucose limitation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Rpd3L complex HDA PubMed 
part_of Rpd3L complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Rpd3L-Expanded complex HDA PubMed 
part_of Sin3-type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sds3p
NP_012182.1
  • Component of the Rpd3L histone deacetylase complex; required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; relocalizes to the cytosol in response to hypoxia; cells defective in SDS3 display pleiotropic phenotypes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    202276..203259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179432.1 → NP_012182.1  TPA: Sds3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012182.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVK2, P40505
    UniProtKB/TrEMBL
    G2WG67
    Conserved Domains (1) summary
    pfam08598
    Location:21 → 310
    Sds3; Sds3-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40505.1

Gene LinkOut

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