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MAM33 Mam33p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854740, updated on 9-Jun-2024

Summary

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Gene symbol
MAM33
Gene description
Mam33p
Primary source
FungiDB:YIL070C
Locus tag
YIL070C
See related
SGD:S000001332; AllianceGenome:SGD:S000001332; VEuPathDB:YIL070C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mitochondrial ribosome binding activity. Involved in aerobic respiration and mitochondrial ribosome assembly. Located in mitochondrial matrix. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 33. Orthologous to human C1QBP (complement C1q binding protein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MAM33 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (230272..231072, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Hop1p Neighboring gene Pci8p Neighboring gene ribosomal 40S subunit protein S24B Neighboring gene SNARE-binding exocyst subunit SEC6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mam33 promotes cytochrome c oxidase subunit I translation in Saccharomyces cerevisiae mitochondria. Roloff GA, et al. Mol Biol Cell, 2015 Aug 15. PMID 26108620, Free PMC Article
  2. Crystal structures and putative interface of Saccharomyces cerevisiae mitochondrial matrix proteins Mmf1 and Mam33. Pu YG, et al. J Struct Biol, 2011 Sep. PMID 21600990
  3. Mam33p, an oligomeric, acidic protein in the mitochondrial matrix of Saccharomyces cerevisiae is related to the human complement receptor gC1q-R. Seytter T, et al. Yeast, 1998 Mar 15. PMID 9559539
  4. The mitospecific domain of Mrp7 (bL27) supports mitochondrial translation during fermentation and is required for effective adaptation to respiration. Anderson JM, et al. Mol Biol Cell, 2022 Jan 1. PMID 34731012, Free PMC Article
  5. p32 protein, a splicing factor 2-associated protein, is localized in mitochondrial matrix and is functionally important in maintaining oxidative phosphorylation. Muta T, et al. J Biol Chem, 1997 Sep 26. PMID 9305894

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. found that Mam33 does not associate with the mature mitoribosome
    Title: The yeast protein Mam33 functions in the assembly of the mitochondrial ribosome.
  2. Authors report that Mam33 is a third COX1 translational activator in yeast mitochondria.
    Title: Mam33 promotes cytochrome c oxidase subunit I translation in Saccharomyces cerevisiae mitochondria.
  3. The results provided the structural insights into the putative function of Mmf1 during mitochondrial protein synthesis via Mam33, a protein binding to mitochondrial ribosomal proteins.
    Title: Crystal structures and putative interface of Saccharomyces cerevisiae mitochondrial matrix proteins Mmf1 and Mam33.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables mitochondrial ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in aerobic respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytosolic ribosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial ribosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mam33p
NP_012194.1
  • Acidic protein of the mitochondrial matrix; binds unassembled large subunit proteins during ribosome assembly; subunit of a complex containing Mrx6p, Pim1p, and Pet20p that may regulate mtDNA replication; related to the human complement receptor gC1q-R

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    230272..231072 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179420.1 → NP_012194.1  TPA: Mam33p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012194.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVL4, P40513, Q6Q5P4
    UniProtKB/TrEMBL
    A0A6A5Q3I0, B3LTS2, C7GKK1, C8ZAH6, N1P219
    Conserved Domains (1) summary
    pfam02330
    Location:57 → 259
    MAM33; Mitochondrial glycoprotein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40513.1

Gene LinkOut

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