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YRB2 Yrb2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854747, updated on 2-Nov-2024

Summary

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Official Symbol
YRB2
Official Full Name
Yrb2p
Primary source
SGD:S000001325
Locus tag
YIL063C
See related
AllianceGenome:SGD:S000001325; FungiDB:YIL063C; VEuPathDB:YIL063C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to contribute to GTPase activator activity. Involved in protein export from nucleus and ribosomal small subunit export from nucleus. Located in cytosol and nucleus. Orthologous to human RANBP3 (RAN binding protein 3) and RANBP3L (RAN binding protein 3 like). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See YRB2 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (242761..243744, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Fis1p Neighboring gene Efm4p Neighboring gene Arc15p Neighboring gene U1 snRNP complex subunit SNP1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The ribotoxin α-sarcin can cleave the sarcin/ricin loop on late 60S pre-ribosomes. Olombrada M, et al. Nucleic Acids Res, 2020 Jun 19. PMID 32365182, Free PMC Article
  2. Requirements for the nuclear export of the small ribosomal subunit. Moy TI, et al. J Cell Sci, 2002 Jul 15. PMID 12082158
  3. A family of Ran binding proteins that includes nucleoporins. Dingwall C, et al. Proc Natl Acad Sci U S A, 1995 Aug 1. PMID 7638224, Free PMC Article
  4. Ltv1 is required for efficient nuclear export of the ribosomal small subunit in Saccharomyces cerevisiae. Seiser RM, et al. Genetics, 2006 Oct. PMID 16888326, Free PMC Article
  5. Yrb2p is a nuclear protein that interacts with Prp20p, a yeast Rcc1 homologue. Taura T, et al. J Biol Chem, 1997 Dec 12. PMID 9395535

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal small subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Yrb2p
NP_012201.1
  • hypothetical protein; involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; relocalizes to the cytosol in response to hypoxia; not essential for viability

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    242761..243744 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179413.1 → NP_012201.1  TPA: Yrb2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012201.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVM1, P40517
    UniProtKB/TrEMBL
    B3LTR6, C8ZAI5, N1P101
    Conserved Domains (1) summary
    smart00160
    Location:193 → 321
    RanBD; Ran-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40517.1

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