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ARC15 Arc15p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854748, updated on 2-Nov-2024

Summary

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Official Symbol
ARC15
Official Full Name
Arc15p
Primary source
SGD:S000001324
Locus tag
YIL062C
See related
AllianceGenome:SGD:S000001324; FungiDB:YIL062C; VEuPathDB:YIL062C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mRNA binding activity and protein-macromolecule adaptor activity. Involved in actin cortical patch organization and mitochondrion inheritance. Part of Arp2/3 protein complex. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to several human genes including ARPC5L (actin related protein 2/3 complex subunit 5 like). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ARC15 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (243998..244462, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Efm4p Neighboring gene Yrb2p Neighboring gene U1 snRNP complex subunit SNP1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Affinity filtration coupled with capillary-based affinity purification for the isolation of protein complexes. Qureshi MS, et al. Anal Biochem, 2013 Aug 1. PMID 23583819
  2. Mechanism of filament nucleation and branch stability revealed by the structure of the Arp2/3 complex at actin branch junctions. Egile C, et al. PLoS Biol, 2005 Nov. PMID 16262445, Free PMC Article
  3. Cofilin, but not profilin, is required for myosin-I-induced actin polymerization and the endocytic uptake in yeast. Idrissi FZ, et al. Mol Biol Cell, 2002 Nov. PMID 12429847, Free PMC Article
  4. Purification of Arp2/3 complex from Saccharomyces cerevisiae. Doolittle LK, et al. Methods Mol Biol, 2013. PMID 23868593, Free PMC Article
  5. A pathway for association of receptors, adaptors, and actin during endocytic internalization. Kaksonen M, et al. Cell, 2003 Nov 14. PMID 14622601

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-macromolecule adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Arp2/3 complex-mediated actin nucleation IEA
Inferred from Electronic Annotation
more info
  
involved_in actin cortical patch organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion inheritance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Arp2/3 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Arp2/3 protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Arp2/3 protein complex IEA
Inferred from Electronic Annotation
more info
  
located_in actin cortical patch IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Arc15p
NP_012202.1
  • Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; has mRNA binding activity

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    243998..244462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179412.1 → NP_012202.1  TPA: Arc15p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012202.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVM2, P40518
    UniProtKB/TrEMBL
    A6ZVL1, B3LTR5, B5VKP0, C7GVY6, C8ZAI6, G2WG86, N1P9C9
    Conserved Domains (1) summary
    pfam04699
    Location:4 → 152
    P16-Arc; ARP2/3 complex 16 kDa subunit (p16-Arc)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40518.1

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