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MMF1 isoleucine biosynthesis protein MMF1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854760, updated on 17-May-2024

Summary

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Gene symbol
MMF1
Gene description
isoleucine biosynthesis protein MMF1
Primary source
FungiDB:YIL051C
Locus tag
YIL051C
See related
SGD:S000001313; AllianceGenome:SGD:S000001313; VEuPathDB:YIL051C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
IBM1
Summary
Predicted to enable deaminase activity. Involved in isoleucine biosynthetic process and mitochondrial translation. Located in mitochondrial matrix. Orthologous to human RIDA (reactive intermediate imine deaminase A homolog). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MMF1 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (257843..258280, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene glycerol-1-phosphatase RHR2 Neighboring gene ribosomal 60S subunit protein L34B Neighboring gene Pcl7p Neighboring gene putative polyprenol reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structures and putative interface of Saccharomyces cerevisiae mitochondrial matrix proteins Mmf1 and Mam33. Pu YG, et al. J Struct Biol, 2011 Sep. PMID 21600990
  2. Bacterial proteins predisposed for targeting to mitochondria. Lucattini R, et al. Mol Biol Evol, 2004 Apr. PMID 14739247
  3. Schizosaccharomyces pombe Pmf1p is structurally and functionally related to Mmf1p of Saccharomyces cerevisiae. Marchini A, et al. Yeast, 2002 Jun 15. PMID 12185840
  4. A member of the YER057c/yjgf/Uk114 family links isoleucine biosynthesis and intact mitochondria maintenance in Saccharomyces cerevisiae. Kim JM, et al. Genes Cells, 2001 Jun. PMID 11442631
  5. Absence of MMF1 disrupts heme biosynthesis by targeting Hem1pin Saccharomyces cerevisiae. Whitaker GH, et al. Yeast, 2021 Dec. PMID 34559917, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Not4-dependent targeting of MMF1 mRNA to mitochondria limits its expression via ribosome pausing, Egd1 ubiquitination, Caf130, no-go-decay and autophagy.
    Title: Not4-dependent targeting of MMF1 mRNA to mitochondria limits its expression via ribosome pausing, Egd1 ubiquitination, Caf130, no-go-decay and autophagy.
  2. Taken together, the data indicate that Mmf1p indirectly contributes to mitochondrial DNA maintenance by preventing 2-aminoacrylate stress derived from mitochondrial amino acid metabolism.
    Title: Mmf1p Couples Amino Acid Metabolism to Mitochondrial DNA Maintenance in Saccharomyces cerevisiae.
  3. The results provided the structural insights into the putative function of Mmf1 during mitochondrial protein synthesis via Mam33, a protein binding to mitochondrial ribosomal proteins.
    Title: Crystal structures and putative interface of Saccharomyces cerevisiae mitochondrial matrix proteins Mmf1 and Mam33.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in isoleucine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial translation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in organonitrogen compound catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
isoleucine biosynthesis protein MMF1
NP_012213.3
  • Mitochondrial protein required for transamination of isoleucine; but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; induction of expression in response to stress is mediated by a Hog1p-regulated antisense RNA and gene looping; interacts genetically with mitochondrial ribosomal protein genes; MMF1 has a paralog, HMF1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    257843..258280 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179401.3 → NP_012213.3  TPA: isoleucine biosynthesis protein MMF1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012213.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVN0, P40185
    UniProtKB/TrEMBL
    A0A6A5PYW1, A6ZVL8, B3LTQ7, C7GVX9, C8ZAJ5, G2WG94, N1P1M0
    Conserved Domains (1) summary
    TIGR00004
    Location:21 → 143
    TIGR00004; reactive intermediate/imine deaminase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40185.1

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