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SCIN scinderin [ Homo sapiens (human) ]

Gene ID: 85477, updated on 5-Mar-2024

Summary

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Official Symbol
SCINprovided by HGNC
Official Full Name
scinderinprovided by HGNC
Primary source
HGNC:HGNC:21695
See related
Ensembl:ENSG00000006747 MIM:613416; AllianceGenome:HGNC:21695
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]).[supplied by OMIM, May 2010]
Expression
Biased expression in small intestine (RPKM 29.7), kidney (RPKM 29.3) and 11 other tissues See more
Orthologs
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Genomic context

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See SCIN in Genome Data Viewer
Location:
7p21.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (12570720..12660182)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (12701807..12791257)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (12610346..12699807)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375156 Neighboring gene small RNA binding exonuclease protection factor La like 5, pseudogene Neighboring gene Sharpr-MPRA regulatory region 5173 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:12536548-12537176 Neighboring gene chromosome 7 open reading frame 78 Neighboring gene taste 2 receptor member 2, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25664 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:12596820-12598019 Neighboring gene uncharacterized LOC107986768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25665 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:12635263-12636462 Neighboring gene Sharpr-MPRA regulatory region 10361 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:12700000-12700549 Neighboring gene uncharacterized LOC105375157 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:12714709-12715908 Neighboring gene apoptosis-inducing, TAF9-like domain 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Clinical Study of SCIN Expression and Dromoter Methylation in Patients with Chronic Myeloid Leukemia]. Zhang ZH, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2019 Jun. PMID 31204912
  2. Decreased SCIN expression, associated with promoter methylation, is a valuable predictor for prognosis in acute myeloid leukemia. Zhang ZH, et al. Mol Carcinog, 2018 Jun. PMID 29457658
  3. Cyclic compressive stress-induced scinderin regulates progress of developmental dysplasia of the hip. Wang CL, et al. Biochem Biophys Res Commun, 2017 Apr 1. PMID 28213129
  4. Scinderin promotes the invasion and metastasis of gastric cancer cells and predicts the outcome of patients. Liu JJ, et al. Cancer Lett, 2016 Jun 28. PMID 27033455, Free PMC Article
  5. Lentivirus-mediated silencing of SCIN inhibits proliferation of human lung carcinoma cells. Liu H, et al. Gene, 2015 Jan 1. PMID 25303873

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The AHR target gene scinderin activates the WNT pathway by facilitating the nuclear translocation of beta-catenin.
    Title: The AHR target gene scinderin activates the WNT pathway by facilitating the nuclear translocation of β-catenin.
  2. down-regulation of SCIN expression may relate with the progression of chronic myeloid leukemia
    Title: [Clinical Study of SCIN Expression and Dromoter Methylation in Patients with Chronic Myeloid Leukemia].
  3. Findings indicate that decreased scinderin (SCIN) expression associated with its promoter methylation is a valuable biomarker for predicting adverse prognosis in acute myeloid leukemia (AML) patients.
    Title: Decreased SCIN expression, associated with promoter methylation, is a valuable predictor for prognosis in acute myeloid leukemia.
  4. Data suggest that scinderin (Scin) played a vital role in the development of developmental dysplasia of the hip (DDH).
    Title: Cyclic compressive stress-induced scinderin regulates progress of developmental dysplasia of the hip.
  5. Epistasis analysis identified a statistically significant interaction between CDC42 and SCIN SNPs which are strongly associated with CDC42 and SCIN gene expression levels and map to regulatory elements in skin cells. This interaction has important biological relevance since CDC42 and SCIN proteins have opposite effects in actin cytoskeleton organization and dynamics, which underlies melanoma cell migration and invasion.
    Title: A comprehensive genome-wide analysis of melanoma Breslow thickness identifies interaction between CDC42 and SCIN genetic variants.
  6. High levels of SCIN expression in gastric cancer tissue correlate with poor prognosis of patients. SCIN enhances the invasion and metastasis of GC cells through activating the Cdc42 pathway to increase the formation of filopodia.
    Title: Scinderin promotes the invasion and metastasis of gastric cancer cells and predicts the outcome of patients.
  7. Suppression of scinderin impairs proliferation and migration of gastric cancer SGC7901 cells and attenuates its epithelialmesenchymal transition process.
    Title: Suppression of scinderin modulates epithelial‑mesenchymal transition markers in highly metastatic gastric cancer cell line SGC‑7901.
  8. SCIN plays an important role in lung carcinoma cell proliferation
    Title: Lentivirus-mediated silencing of SCIN inhibits proliferation of human lung carcinoma cells.
  9. These results suggest that SCIN plays an important role in the proliferation of prostate cancer cells and lentivirus-mediated inhibition of SCIN expression may be a potential therapeutic method for the treatment of prostate cancer
    Title: Suppression of SCIN inhibits human prostate cancer cell proliferation and induces G0/G1 phase arrest.
  10. Scinderin expression does not correlate with prognosis in head and neck cancer.
    Title: Expression of EPHRIN-A1, SCINDERIN and MHC class I molecules in head and neck cancers and relationship with the prognostic value of intratumoral CD8+ T cells.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1905

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding TAS
Traceable Author Statement
more info
 PubMed 
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables actin binding TAS
Traceable Author Statement
more info
 PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables calcium ion binding TAS
Traceable Author Statement
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylserine binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in actin filament capping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin filament severing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament severing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin nucleation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-ion regulated exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of actin nucleation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of megakaryocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of chondrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sequestering of actin monomers IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in brush border IEA
Inferred from Electronic Annotation
more info
  
located_in cell cortex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular exosome HDA PubMed 
located_in podosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
scinderin
Names
adseverin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112706.3 → NP_001106177.1  scinderin isoform 1

    See identical proteins and their annotated locations for NP_001106177.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC011891, AK290363, BC021090, CA447429
    Consensus CDS
    CCDS47545.1
    UniProtKB/Swiss-Prot
    A8K2U8, Q8NBZ6, Q8WU97, Q96JC7, Q96PY2, Q9Y6U3
    Related
    ENSP00000297029.5, ENST00000297029.10
    Conserved Domains (6) summary
    cd11288
    Location:508 → 598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:136 → 225
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:10 → 121
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:613 → 711
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:246 → 346
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:390 → 486
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  2. NM_033128.3 → NP_149119.1  scinderin isoform 2

    See identical proteins and their annotated locations for NP_149119.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks three exons and includes an alternate exon in the 5' end resulting in use of a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK027778, CA447429
    Consensus CDS
    CCDS47546.1
    UniProtKB/TrEMBL
    Q8NBV9
    Related
    ENSP00000430997.1, ENST00000519209.5
    Conserved Domains (4) summary
    cd11288
    Location:261 → 351
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:366 → 464
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:1 → 99
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:143 → 239
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

RNA

  1. NR_156701.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC011891, AK290363, BC021090, CA447429

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    12570720..12660182
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    12701807..12791257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y6U3.4 GenPept UniProtKB/Swiss-Prot:Q9Y6U3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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