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CKA1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854776, updated on 22-Aug-2024

Summary

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Official Symbol
CKA1
Primary source
FungiDB:YIL035C
Locus tag
YIL035C
See related
SGD:S000001297; AllianceGenome:SGD:S000001297; VEuPathDB:YIL035C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including donor selection; protein phosphorylation; and regulation of transcription, DNA-templated. Part of UTP-C complex and protein kinase CK2 complex. Orthologous to several human genes including CSNK2A1 (casein kinase 2 alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CKA1 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (287790..288908, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene pheromone-regulated protein PRM2 Neighboring gene Cst6p Neighboring gene F-actin-capping protein subunit beta Neighboring gene cAMP-dependent protein kinase regulatory subunit BCY1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation, sequencing, and disruption of the CKA1 gene encoding the alpha subunit of yeast casein kinase II. Chen-Wu JL, et al. Mol Cell Biol, 1988 Nov. PMID 3062376, Free PMC Article
  2. Catalytic activity of mutants of yeast protein kinase CK2alpha. Sajnaga E, et al. Acta Biochim Pol, 2008. PMID 19015772
  3. Minimal CK2 activity required for yeast growth. Hermosilla GH, et al. Mol Cell Biochem, 2005 Jun. PMID 16335527
  4. Different properties of four molecular forms of protein kinase CK2 from Saccharomyces cerevisiae. Domańska K, et al. Acta Biochim Pol, 2005. PMID 16265593
  5. Phosphorylation of histone H4 serine 1 during DNA damage requires casein kinase II in S. cerevisiae. Cheung WL, et al. Curr Biol, 2005 Apr 12. PMID 15823538

See all (163) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of CK2-dependent phosphorylation of Ifh1 and Crf1 in transcriptional regulation of ribosomal protein genes in Saccharomyces cerevisiae has been described.
    Title: Role of CK2-dependent phosphorylation of Ifh1 and Crf1 in transcriptional regulation of ribosomal protein genes in Saccharomyces cerevisiae.
  2. The authors provide strong evidence that Cka1p regulates Ycf1p function via phosphorylation of Ser251.
    Title: Suppression of Ycf1p function by Cka1p-dependent phosphorylation is attenuated in response to salt stress.
  3. protein kinase CK2 phosphorylates Ser(361) on Sgt1, and this phosphorylation inhibits Sgt1 dimerization
    Title: Sgt1 dimerization is negatively regulated by protein kinase CK2-mediated phosphorylation at Ser361.
  4. Studies in yeast and in human cells demonstrate that the different forms of CK2 interact with a large number of cellular proteins.
    Title: The emerging CK2 interactome: insights into the regulation and functions of CK2.
  5. Cka1p may regulate Ycf1p function through phosphorylation of Ser-251 either directly or indirectly.
    Title: Negative regulation of the yeast ABC transporter Ycf1p by phosphorylation within its N-terminal extension.
  6. Yeast transcription elongation factor Elf1 has been identified as a new substrate for protein kinase CK2 and coimmunoprecipitation shows that Elf1 interacts with catalytic (alpha and alpha') as well as regulatory (beta and beta') subunits of CK2.
    Title: Yeast elf1 factor is phosphorylated and interacts with protein kinase CK2.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity HDA PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in donor selection IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase I IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase I IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase III IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of UTP-C complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein kinase CK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein kinase CK2 complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
casein kinase 2 catalytic subunit CKA1
NP_012229.1
  • Alpha catalytic subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    287790..288908 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179385.1 → NP_012229.1  TPA: casein kinase 2 catalytic subunit CKA1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012229.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVP7, P15790
    UniProtKB/TrEMBL
    A6ZVN4, B3LTP1, B5VKR1, C7GVW3, C8ZAL1, G2WGB1, N1P271
    Conserved Domains (1) summary
    cd14132
    Location:21 → 363
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15790.1

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