YIA6 NAD+ transporter [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: YIA6
Official Full Name: NAD+ transporter
Primary source: SGD:S000001268
Locus tag: YIL006W
See related: AllianceGenome:SGD:S000001268; FungiDB:YIL006W; VEuPathDB:YIL006W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: NDT1
Summary: Enables NAD transmembrane transporter activity. Involved in NAD transmembrane transport and mitochondrial pyruvate transmembrane transport. Located in mitochondrion. Orthologous to human SLC25A32 (solute carrier family 25 member 32). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables NAD transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables NAD transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables nucleotide transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NAD transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in NAD transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in NAD transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in NAD transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial pyruvate transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleotide transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_012260.1

Mitochondrial NAD+ transporter; involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs; YIA6 has a paralog, YEA6, that arose from the whole genome duplication; human NAD+ transporter MCART1/SLC25A51 functionally complements the yia6 yea6 double null mutant, and yeast YIA6 reciprocally complements defects in MCART1/SLC25A51 null cells