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BET1 Bet1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854813, updated on 2-Nov-2024

Summary

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Official Symbol
BET1
Official Full Name
Bet1p
Primary source
SGD:S000001266
Locus tag
YIL004C
See related
AllianceGenome:SGD:S000001266; FungiDB:YIL004C; VEuPathDB:YIL004C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SLY12
Summary
Enables SNAP receptor activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; and vesicle fusion. Located in COPII-coated ER to Golgi transport vesicle and endoplasmic reticulum membrane. Part of SNARE complex. Human ortholog(s) of this gene implicated in uterine fibroid. Orthologous to several human genes including BET1 (Bet1 golgi vesicular membrane trafficking protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See BET1 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
2
Sequence:
Chromosome: IX; NC_001141.2 (347946..348505, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene NAD+ transporter Neighboring gene protein disulfide isomerase EPS1 Neighboring gene iron-sulfur cluster assembly protein CFD1 Neighboring gene Cmi7p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bos1p, a membrane protein required for ER to Golgi transport in yeast, co-purifies with the carrier vesicles and with Bet1p and the ER membrane. Newman AP, et al. EMBO J, 1992 Oct. PMID 1396561, Free PMC Article
  2. Bet1p activates the v-SNARE Bos1p. Stone S, et al. Mol Biol Cell, 1997 Jul. PMID 9243499, Free PMC Article
  3. Nucleotide sequence and analysis of the centromeric region of yeast chromosome IX. Voss H, et al. Yeast, 1995 Jan. PMID 7762303
  4. Characterization of new mutants in the early part of the yeast secretory pathway isolated by a [3H]mannose suicide selection. Newman AP, et al. J Cell Biol, 1987 Oct. PMID 3312234, Free PMC Article
  5. The BOS1 gene encodes an essential 27-kD putative membrane protein that is required for vesicular transport from the ER to the Golgi complex in yeast. Shim J, et al. J Cell Biol, 1991 Apr. PMID 2007627, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables SNAP receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables SNAP receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in membrane fusion IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle fusion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in COPII-coated ER to Golgi transport vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
part_of SNARE complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Bet1p
NP_012262.3
  • Type II membrane protein required for vesicular transport; required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    347946..348505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179354.3 → NP_012262.3  TPA: Bet1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012262.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVS6, P22804
    UniProtKB/TrEMBL
    A6ZVR4, B3LTL3, C8ZAP5, G2WGE2, N1P0P7
    Conserved Domains (1) summary
    cd15853
    Location:55 → 112
    SNARE_Bet1; SNARE motif of Bet1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P22804.1

Gene LinkOut

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