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MRS1 Mrs1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854839, updated on 2-Nov-2024

Summary

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Official Symbol
MRS1
Official Full Name
Mrs1p
Primary source
SGD:S000001460
Locus tag
YIR021W
See related
AllianceGenome:SGD:S000001460; FungiDB:YIR021W; VEuPathDB:YIR021W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PET157
Summary
Enables RNA binding activity. Involved in Group I intron splicing and mitochondrial RNA processing. Located in mitochondrion. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MRS1 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (397294..398385)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene signal peptidase complex catalytic subunit SEC11

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A yeast nuclear gene, MRS1, involved in mitochondrial RNA splicing: nucleotide sequence and mutational analysis of two overlapping open reading frames on opposite strands. Kreike J, et al. EMBO J, 1987 Jul. PMID 2443348, Free PMC Article
  2. Cloning of a nuclear gene MRS1 involved in the excision of a single group I intron (bI3) from the mitochondrial COB transcript in S. cerevisiae. Kreike J, et al. Curr Genet, 1986. PMID 2834089
  3. Two group I mitochondrial introns in the cob-box and coxI genes require the same MRS1/PET157 nuclear gene product for splicing. Bousquet I, et al. Curr Genet, 1990 Aug. PMID 1699677
  4. Mitochondrial protein synthesis is not required for efficient excision of intron aI5 beta from COX1 pre-mRNA in Saccharomyces cerevisiae. Johnson CH, et al. Mol Gen Genet, 1997 Sep. PMID 9341683
  5. Site-directed mutagenesis of the yeast resolving enzyme Cce1 reveals catalytic residues and relationship with the intron-splicing factor Mrs1. Wardleworth BN, et al. J Biol Chem, 2000 Aug 4. PMID 10825168

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that Mrs1 binds a ubiquitous RNA tertiary structure motif, the GNRA tetraloop-receptor interaction, at two sites in the bI3 RNA.
    Title: The Mrs1 splicing factor binds the bI3 group I intron at each of two tetraloop-receptor motifs.
  2. defects in Suv3p result in accumulation of stable, excised group I intron ribonucleoproteins, which result in sequestration of Mrs1p, and a concomitant reduction in splicing of aI5beta
    Title: Splicing of yeast aI5beta group I intron requires SUV3 to recycle MRS1 via mitochondrial degradosome-promoted decay of excised intron ribonucleoprotein (RNP).
  3. Data suggest that Mrs1p stabilizes RNA structure and promotes the first step in splicing, while Mss116p acts after the first step and, utilizing ATP hydrolysis, specifically enhances the efficiency of exon ligation.
    Title: A DExH/D-box protein coordinates the two steps of splicing in a group I intron.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables Y-form DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables crossed form four-way junction DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flap-structured DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in Group I intron splicing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial RNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial genome maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Mrs1p
NP_012287.3
  • Splicing protein; required for splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA; MRS1 has a paralog, CCE1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    397294..398385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179543.3 → NP_012287.3  TPA: Mrs1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012287.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVV1, P07266
    UniProtKB/TrEMBL
    A6ZVU0, G2WFU8, N1P0R5
    Conserved Domains (1) summary
    pfam09159
    Location:83 → 357
    Ydc2-catalyt; Mitochondrial resolvase Ydc2 / RNA splicing MRS1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07266.2

Gene LinkOut

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