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DAL81 Dal81p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854841, updated on 2-Nov-2024

Summary

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Official Symbol
DAL81
Official Full Name
Dal81p
Primary source
SGD:S000001462
Locus tag
YIR023W
See related
AllianceGenome:SGD:S000001462; FungiDB:YIR023W; VEuPathDB:YIR023W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
UGA35
Summary
Enables transcription coactivator activity. Involved in RNA polymerase II preinitiation complex assembly; nitrogen catabolite activation of transcription from RNA polymerase II promoter; and positive regulation of catabolic process. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See DAL81 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (399777..402689)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene signal peptidase complex catalytic subunit SEC11 Neighboring gene Ina22p Neighboring gene Mnd2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic regulation of nitrogen metabolism in the fungi. Marzluf GA. Microbiol Mol Biol Rev, 1997 Mar. PMID 9106362, Free PMC Article
  2. The pleiotropic UGA35(DURL) regulatory gene of Saccharomyces cerevisiae: cloning, sequence and identity with the DAL81 gene. Coornaert D, et al. Gene, 1991 Jan 15. PMID 1999281
  3. Prevention of GABA reduction during dough fermentation using a baker's yeast dal81 mutant. Ando A, et al. J Biosci Bioeng, 2016 Oct. PMID 27056577
  4. A gene product needed for induction of allantoin system genes in Saccharomyces cerevisiae but not for their transcriptional activation. Bricmont PA, et al. Mol Cell Biol, 1989 Sep. PMID 2674683, Free PMC Article
  5. Dal81 Regulates Expression of Arginine Metabolism Genes in Candida parapsilosis. Turner SA, et al. mSphere, 2018 Mar-Apr. PMID 29564399, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Uga3 and Dal81 transcription factors depend on GABA to interact with UGA genes. Dal81 is necessary for Uga3 binding to UGA promoters. Uga3 factor acts as a bridge between Dal81 and DNA.
    Title: Interplay between the transcription factors acting on the GATA- and GABA-responsive elements of Saccharomyces cerevisiae UGA promoters.
  2. Yeast zinc cluster proteins Dal81 and Uga3 cooperate by targeting common coactivators for transcriptional activation of gamma-aminobutyrate responsive genes.
    Title: Yeast zinc cluster proteins Dal81 and Uga3 cooperate by targeting common coactivators for transcriptional activation of γ-aminobutyrate responsive genes.
  3. Dal81 indiscriminately amplifies the transactivation potential of both full-length and processed Stp1 and Stp2 by facilitating promoter binding.
    Title: Dal81 enhances Stp1- and Stp2-dependent transcription necessitating negative modulation by inner nuclear membrane protein Asi1 in Saccharomyces cerevisiae.
  4. Uga35/Dal81 is a transcription factor under the control of the external amino acid sensing pathway.
    Title: The external amino acid signaling pathway promotes activation of Stp1 and Uga35/Dal81 transcription factors for induction of the AGP1 gene in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA polymerase II preinitiation complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in RNA polymerase II preinitiation complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nitrogen catabolite activation of transcription from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nitrogen catabolite activation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nitrogen catabolite activation of transcription from RNA polymerase II promoter IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in positive regulation of gamma-aminobutyric acid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of urea catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Dal81p
NP_012289.3
  • Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    399777..402689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179545.3 → NP_012289.3  TPA: Dal81p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012289.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVV4, P21657
    UniProtKB/TrEMBL
    A0A0S3TFJ8, G2WFV1, N1P2B7
    Conserved Domains (3) summary
    cd12148
    Location:319 → 732
    fungal_TF_MHR; fungal transcription factor regulatory middle homology region
    pfam05109
    Location:729 → 963
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00172
    Location:149 → 188
    Zn_clus; Fungal Zn(2)-Cys(6) binuclear cluster domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21657.3

Gene LinkOut

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