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SEC65 RNA-binding signal recognition particle subunit SEC65 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854866, updated on 18-Sep-2024

Summary

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Official Symbol
SEC65
Official Full Name
RNA-binding signal recognition particle subunit SEC65
Primary source
SGD:S000004573
Locus tag
YML105C
See related
AllianceGenome:SGD:S000004573; FungiDB:YML105C; VEuPathDB:YML105C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 7S RNA binding activity. Involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Part of signal recognition particle, endoplasmic reticulum targeting. Orthologous to human SRP19 (signal recognition particle 19). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SEC65 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (57866..58687, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Pml39p Neighboring gene orotate phosphoribosyltransferase URA5 Neighboring gene Mdm1p Neighboring gene Nup188p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutants affecting the structure of the cortical endoplasmic reticulum in Saccharomyces cerevisiae. Prinz WA, et al. J Cell Biol, 2000 Aug 7. PMID 10931860, Free PMC Article
  2. Deletion analysis of yeast Sec65p reveals a central domain that is sufficient for function in vivo. Regnacq M, et al. Mol Microbiol, 1998 Aug. PMID 9723915
  3. Isolation and cloning of the Yarrowia lipolytica SEC65 gene, a component of the yeast signal recognition particle displaying homology with the human SRP19 gene. Sánchez M, et al. Gene, 1997 Dec 5. PMID 9426009
  4. SRP samples nascent chains for the presence of signal sequences by interacting with ribosomes at a discrete step during translation elongation. Ogg SC, et al. Cell, 1995 Jun 30. PMID 7600575
  5. Folding and intracellular transport of the yeast plasma-membrane H(+)-ATPase: effects of mutations in KAR2 and SEC65. Chang A, et al. Proc Natl Acad Sci U S A, 1993 Jun 15. PMID 8516333, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 7S RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 7S RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables 7S RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in SRP-dependent cotranslational protein targeting to membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of signal recognition particle IEA
Inferred from Electronic Annotation
more info
  
part_of signal recognition particle, endoplasmic reticulum targeting IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal recognition particle, endoplasmic reticulum targeting IDA
Inferred from Direct Assay
more info
 PubMed 
part_of signal recognition particle, endoplasmic reticulum targeting IEA
Inferred from Electronic Annotation
more info
  
part_of signal recognition particle, endoplasmic reticulum targeting IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
RNA-binding signal recognition particle subunit SEC65
NP_013602.1
  • Subunit of the signal recognition particle (SRP); involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    57866..58687 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182467.1 → NP_013602.1  TPA: RNA-binding signal recognition particle subunit SEC65 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013602.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0H9, P29478
    UniProtKB/TrEMBL
    A6ZLV9, B3LLF4, B5VP26, C7GV87, C8ZE97, G2WJV1, N1NXE7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P29478.1

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