RPM2 ribonuclease P [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: RPM2
Gene description: ribonuclease P
Primary source: FungiDB:YML091C
Locus tag: YML091C
See related: SGD:S000004556; AllianceGenome:SGD:S000004556; VEuPathDB:YML091C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to ribonuclease P activity. Involved in several processes, including RNA processing; cytoplasmic translation; and positive regulation of transcription by RNA polymerase II. Located in mitochondrial matrix and nucleus. Part of mitochondrial ribonuclease P complex. [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Rpm2p has a transcriptional activation domain and plays a role in defining the mRNAs for some nucleus-encoded mitochondrial components.
Title: Rpm2p, a component of yeast mitochondrial RNase P, acts as a transcriptional activator in the nucleus.
Rpm2p appears to function as a coordinator of transcription and mRNA storage/decay in P bodies.
Title: Rpm2p, a protein subunit of mitochondrial RNase P, physically and genetically interacts with cytoplasmic processing bodies.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to ribonuclease P activity	IDA Inferred from Direct Assay more info	PubMed
enables ribonuclease P activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoplasmic translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA processing	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mRNA processing	IPI Inferred from Physical Interaction more info	PubMed
involved_in mitochondrial tRNA 5'-end processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA 5'-leader removal	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
part_of mitochondrial ribonuclease P complex	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of ribonuclease P complex	IDA Inferred from Direct Assay more info	PubMed

NP_013619.1

Protein subunit of mitochondrial RNase P; has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus

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The following sections contain reference sequences that belong to a specific genome build. Explain